Author:
Calabrese Fiorella,Lunardi Francesca,Baldasso Elisa,Pezzuto Federica,Kilitci Asuman,Olteanu Gheorghe-Emilian,Del Vecchio Claudia,Fortarezza Francesco,Boscolo Annalisa,Schiavon Marco,Vedovelli Luca,Cattelan Annamaria,Gregori Dario,Rea Federico,Navalesi Paolo
Abstract
AbstractCOVID-19-related acute respiratory distress syndrome (CARDS) is associated with high mortality rates. We still have limited knowledge of the complex alterations developing in the lung microenvironment. The goal of the present study was to comprehensively analyze the cellular components, inflammatory signature, and respiratory pathogens in bronchoalveolar lavage (BAL) of CARDS patients (16) in comparison to those of other invasively mechanically ventilated patients (24). In CARDS patients, BAL analysis revealed: SARS-CoV-2 infection frequently associated with other respiratory pathogens, significantly higher neutrophil granulocyte percentage, remarkably low interferon-gamma expression, and high levels of interleukins (IL)-1β and IL-9. The most important predictive variables for worse outcomes were age, IL-18 expression, and BAL neutrophilia. To the best of our knowledge, this is the first study that was able to identify, through a comprehensive analysis of BAL, several aspects relevant to the complex pathophysiology of CARDS.
Funder
Gilead Fellowship Program 2021
Università degli Studi di Padova
Intesa San Paolo Vita Bank
Publisher
Springer Science and Business Media LLC
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