Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention
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Published:2020-01-16
Issue:1
Volume:22
Page:
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ISSN:1532-429X
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Container-title:Journal of Cardiovascular Magnetic Resonance
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language:en
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Short-container-title:J Cardiovasc Magn Reson
Author:
Hosoda Hayato, Asaumi YasuhideORCID, Noguchi Teruo, Morita Yoshiaki, Kataoka Yu, Otsuka Fumiyuki, Nakao Kazuhiro, Fujino Masashi, Nagai Toshiyuki, Nakai Michikazu, Nishimura Kunihiro, Kono Atsushi, Komori Yoshiaki, Hoshi Tomoya, Sato Akira, Kawasaki Tomohiro, Izumi Chisato, Kusano Kengo, Fukuda Tetsuya, Yasuda Satoshi
Abstract
Abstract
Background
Periprocedural myocardial injury (pMI) is a common complication of elective percutaneous coronary intervention (PCI) that reduces some of the beneficial effects of coronary revascularization and impacts the risk of cardiovascular events. We developed a 3-dimensional volumetric cardiovascular magnetic resonance (CMR) method to evaluate coronary high intensity plaques and investigated their association with pMI after elective PCI.
Methods
Between October 2012 and October 2016, 141 patients with stable coronary artery disease underwent T1-weighted CMR imaging before PCI. A conventional 2-dimensional CMR plaque-to-myocardial signal intensity ratio (2D-PMR) and the newly developed 3-dimensional integral of PMR (3Di-PMR) were measured. 3Di-PMR was determined as the sum of PMRs above a threshold of > 1.0 for voxels in a target plaque. pMI was defined as high-sensitivity cardiac troponin T > 0.07 ng/mL.
Results
pMI following PCI was observed in 46 patients (33%). 3Di-PMR was significantly higher in patients with pMI than those without pMI. The optimal 3Di-PMR cutoff value for predicting pMI was 51 PMR*mm3 and the area under the receiver operating characteristic curve (0.753) was significantly greater than that for 2D-PMR (0.683, P = 0.015). 3Di-PMR was positively correlated with lipid volume (r = 0.449, P < 0.001) based on intravascular ultrasound.
Stepwise multivariable analysis showed that 3Di-PMR ≥ 51 PMR*mm3 and the presence of a side branch at the PCI target lesion site were significant predictors of pMI (odds ratio [OR], 11.9; 95% confidence interval [CI], 4.6–30.4, P < 0.001; and OR, 4.14; 95% CI, 1.6–11.1, P = 0.005, respectively).
Conclusions
3Di-PMR coronary assessment facilitates risk stratification for pMI after elective PCI.
Trial registration
retrospectively registered.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,Radiology Nuclear Medicine and imaging,Radiological and Ultrasound Technology
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