Effect of Eicosapentaenoic Acid/Docosahexaenoic Acid on Coronary High-Intensity Plaques Detected Using Noncontrast T1-weighted Imaging: The AQUAMARINE EPA/DHA Randomized Study

Author:

Nakao Kazuhiro1,Noguchi Teruo1,Miura Hiroyuki1,Asaumi Yasuhide1,Morita Yoshiaki2,Takeuchi Satoshi1,Matama Hideo1,Sawada Keniciro1,Doi Takahito1,Hosoda Hayato1,Nakashima Takahiro1,Honda Satoshi1,Fujino Masashi1,Yoneda Shuichi1,Kawakami Shoji1,Nagai Toshiyuki1,Nishihira Kensaku1,Kanaya Tomoaki1,Otsuka Fumiyuki1,Nakanishi Michio1,Kataoka Yu1,Tahara Yoshio1,Goto Yoichi1,Kusano Kengo1,Yamamoto Haruko3,Omae Katsuhiro4,Ogawa Hisao1,Yasuda Satoshi1

Affiliation:

1. Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Centre

2. Department of Radiology, National Cerebral and Cardiovascular Centre

3. Centre for Advancing Clinical and Translational Science, National Cerebral and Cardiovascular Centre

4. Department of Data Science, National Cerebral and Cardiovascular Centre

Publisher

Japan Atherosclerosis Society

Subject

Biochemistry (medical),Cardiology and Cardiovascular Medicine,Internal Medicine

Reference26 articles.

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2. 2) Mora S, Wenger NK, Demicco DA, Breazna A, Boekholdt SM, Arsenault BJ, Deedwania P, Kastelein JJ, Waters DD: Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the Treating to New Targets (TNT) study. Circulation, 2012; 125: 1979-1987

3. 3) Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K, Investigators JElisJ: Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet, 2007; 369: 1090-1098

4. 4) Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT, Juliano RA, Jiao L, Granowitz C, Tardif JC, Ballantyne CM, Investigators R-I: Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med, 2019; 380: 11-22

5. 5) Nicholls SJ, Lincoff AM, Garcia M, Bash D, Ballantyne CM, Barter PJ, Davidson MH, Kastelein JJP, Koenig W, McGuire DK, Mozaffarian D, Ridker PM, Ray KK, Katona BG, Himmelmann A, Loss LE, Rensfeldt M, Lundström T, Agrawal R, Menon V, Wolski K, Nissen SE: Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial. JAMA, 2020; 324: 2268-2280

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