cGAS-STING, an important pathway in cancer immunotherapy

Author:

Jiang Minlin,Chen Peixin,Wang Lei,Li Wei,Chen Bin,Liu Yu,Wang Hao,Zhao Sha,Ye Lingyun,He Yayi,Zhou CaicunORCID

Abstract

AbstractCytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therapy study with great results achieved in pre-clinical work. Recent progress in the mechanical understanding of STING pathway in IFN production and T cell priming, indicates its promising role for cancer immunotherapy. STING agonists co-administrated with other cancer immunotherapies, including cancer vaccines, immune checkpoint inhibitors such as anti-programmed death 1 and cytotoxic T lymphocyte-associated antigen 4 antibodies, and adoptive T cell transfer therapies, would hold a promise of treating medium and advanced cancers. Despite the applications of STING agonists in cancer immunotherapy, lots of obstacles remain for further study. In this review, we mainly examine the biological characters, current applications, challenges, and future directions of cGAS-STING in cancer immunotherapy.

Funder

National Natural Science Foundation of China

Shanghai Pujiang Program

Shanghai Municipal Commission of Health and Family Planning Program

National key research & development project

Shanghai Shen Kang Hospital Development Center Clinical Research Plan of SHDC

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Molecular Biology,Hematology

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