Development of a Cytosolic DNA Sensor Agonist Using GALA Peptide-Conjugated DNA and Long Single-Stranded DNA-Reference-Cited by-同舟云学术

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Development of a Cytosolic DNA Sensor Agonist Using GALA Peptide-Conjugated DNA and Long Single-Stranded DNA

Published:2024-02-06 Issue:3 Volume:21 Page:1204-1213
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Umemura Keisuke¹^ORCID,Kawamoto Yusuke¹^ORCID,Takahashi Yuki¹^ORCID,Takakura Yoshinobu¹^ORCID

Affiliation:

1. Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan

Funder

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00840

Reference34 articles.

1. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

2. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

3. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

4. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

5. IFI16 is an innate immune sensor for intracellular DNA

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