Abstract
AbstractWound healing, tissue repair and regenerative medicine are in great demand, and great achievements in these fields have been made. The traditional strategy of tissue repair and regeneration has focused on the level of tissues and organs directly; however, the basic process of repair at the cell level is often neglected. Because the cell is the basic unit of organism structure and function; cell damage is caused first by ischemia or ischemia-reperfusion after severe trauma and injury. Then, damage to tissues and organs occurs with massive cell damage, apoptosis and even cell death. Thus, how to achieve the aim of perfect repair and regeneration? The basic process of tissue or organ repair and regeneration should involve repair of cells first, then tissues and organs. In this manuscript, it is my consideration about how to repair the cell first, then regenerate the tissues and organs.
Publisher
Springer Science and Business Media LLC
Reference8 articles.
1. Fu XB, Shen ZY, Chen YL, et al. Randomised placebo-controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burns. Lancet. 1998;352:1661–4.
2. Fu XB, Shen ZY, Chen YL, et al. Recombinant bovine basic fibroblast growth factor accelerates wound healing in patients with burns, donor sites and chronic dermal ulcers. Chin Med J. 2000;113(4):367–71.
3. Qin H, Zhao AD, Sun ML, Ma K, Fu XB. Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors. Mil Med Res. 2020;7(1):52. https://doi.org/10.1186/s40779-020-00284-2.
4. Zhao AD, Qin H, Sun ML, Ma K, Fu XB. Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules. Mil Med Res. 2020;7(1):42. https://doi.org/10.1186/s40779-020-00271-7.
5. Xiao J, Lin ZF, Qin H, Zheng ZL, Gong FH, et al. Growth factor regulatory system: a new system for not truly recognized organisms. Sci China Life Sci. 2020;63(3):443–6. https://doi.org/10.1007/s11427-019-1590-x.
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献