Comprehensive analysis of T-cell regulatory factors and tumor immune microenvironment in stomach adenocarcinoma

Author:

Wang Shuchang,Zhang Weifeng,Wu Xinrui,Zhu Zhu,Chen Yuanbiao,Liu Wangrui,Xu Junnfei,Chen Li,Zhuang Chun

Abstract

Abstract Background Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide and is associated with high morbidity and mortality rates. However, the specific biomarkers used to predict the postoperative prognosis of patients with gastric cancer remain unknown. Recent research has shown that the tumor microenvironment (TME) has an increasingly positive effect on anti-tumor activity. This study aims to build signatures to study the effect of certain genes on gastric cancer. Methods Expression profiles of 37 T cell-related genes and their TME characteristics were comprehensively analyzed. A risk signature was constructed and validated based on the screened T cell-related genes, and the roles of hub genes in GC were experimentally validated. Results A novel T cell-related gene signature was constructed based on CD5, ABCA8, SERPINE2, ESM1, SERPINA5, and NMU. The high-risk group indicated lower overall survival (OS), poorer immune efficacy, and higher drug resistance, with SERPINE2 promoting GC cell proliferation, according to experiments. SERPINE2 and CXCL12 were significantly correlated, indicating poor OS via the Youjiang cohort. Conclusions This study identified T cell-related genes in patients with stomach adenocarcinoma (STAD) for prognosis estimation and proposed potential immunotherapeutic targets for STAD.

Funder

Shanghai Anticancer Association EYAS PROJECT

engineering and medical science cooperation project of Shanghai Jiao Tong University

Publisher

Springer Science and Business Media LLC

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