Predictive Factors of Immunotherapy in Gastric Cancer: A 2024 Update

Author:

Bintintan Vasile1,Burz Claudia23ORCID,Pintea Irena3,Muntean Adriana3ORCID,Deleanu Diana3,Lupan Iulia4,Samasca Gabriel3ORCID

Affiliation:

1. Department of Surgery 1, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania

2. Institute of Oncology, “Prof. Ion Chiricuta”, 400015 Cluj-Napoca, Romania

3. Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania

4. Department of Molecular Biology, Babes-Bolyai University, 400084 Cluj-Napoca, Romania

Abstract

Many studies on gastric cancer treatment have identified predictors of immunotherapy benefits. This article provides an update on the major developments in research related to predictive factors of immunotherapy for gastric cancer. We used the search term “predictive factors, immunotherapy, gastric cancer” to find the most current publications in the PubMed database related to predictive factors of immunotherapy in gastric cancer. Programmed cell death, genetic, and immunological factors are the main study topics of immunotherapy’s predictive factors in gastric cancer. Other preventive factors for immunotherapy in gastric cancer were also found, including clinical factors, tumor microenvironment factors, imaging factors, and extracellular factors. Since there is currently no effective treatment for gastric cancer, we strongly propose that these studies be prioritized.

Publisher

MDPI AG

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