Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program

Author:

Adenis Antoine,de la Fouchardiere Christelle,Paule Bernard,Burtin Pascal,Tougeron David,Wallet Jennifer,Dourthe Louis-Marie,Etienne Pierre-Luc,Mineur Laurent,Clisant Stéphanie,Phelip Jean-Marc,Kramar Andrew,Andre Thierry

Funder

Bayer HealthCare

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

Reference6 articles.

1. Mross K, Frost A, Steinbild S, Hedbom S, Buchert M, Fasol U, et al. Phase I dose-escalation study of regorafenib (BAY 73 4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors. Clin Cancer Res. 2012;18:2658–67.

2. Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013;381:303–12.

3. Li J, Qin S, Xu R, Yau TCC, Ma B, Pan H, et al. Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2015;16:619–29.

4. Tabernero J, Lenz HJ, Siena S, Sobrero A, Falcone A, Ychou M, et al. Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial. Lancet Oncol. 2015;16:937–48.

5. Van Cutsem E, Ciardiello F, Seitz JF, Hofheinz RD, Verma U, Garcia-Carbonero R, et al. Results from the large, open-label phase 3b CONSIGN study of regorafenib in patients with previously treated metastatic colorectal cancer. ESMO 17th World Congress on Gastrointestinal Cancer, 01–04 July 2015, Barcelona, Spain. Ann Oncol. 2015;26 suppl 4:Abstract LBA-05.

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