What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420)

Author:

French David P.ORCID,Astley Susan,Brentnall Adam R.,Cuzick Jack,Dobrashian Richard,Duffy Stephen W.,Gorman Louise S.,Harkness Elaine F.,Harrison Fiona,Harvie Michelle,Howell Anthony,Jerrison Andrew,Machin Matthew,Maxwell Anthony J.,McWilliams Lorna,Payne Katherine,Qureshi Nadeem,Ruane Helen,Sampson Sarah,Stavrinos Paula,Thorpe Emma,Ulph Fiona,van Staa Tjeerd,Woof Victoria,Evans D. Gareth

Funder

Programme Grants for Applied Research

Manchester Biomedical Research Centre

Genesis Research Trust

Prevent Breast Cancer

Breast Cancer Now

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

Reference69 articles.

1. Cancer Research UK. Breast cancer diagnosis and treatment statistics. Available from: http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer#heading-Zero (Retrieved 6 March 2018)..

2. King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science. 2003;302:643–6.

3. Tryggvadottir L, Sigvaldason H, Olafsdottir GH, et al. Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920-2000. J Natl Cancer Inst. 2006;98(2):116–22.

4. Evans DG, Shenton A, Woodward E, et al. Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in the service setting: higher risk in recent birth cohorts. BMC Cancer. 2008;8:155.

5. NHS Digital. Breast Screening Programme, England, 2016–17. Available from: https://digital.nhs.uk/catalogue/PUB30195 (Retrieved 6 March 2018).

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