Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2-Reference-Cited by-同舟云学术

Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2

Published:2003-10-24 Issue:5645 Volume:302 Page:643-646
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

King Mary-Claire¹²³,Marks Joan H.¹²³,Mandell Jessica B.¹²³

Affiliation:

1. Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA.

2. Sarah Lawrence College Graduate Program in Human Genetics, Bronxville, NY 10708, USA.

3. The New York Breast Cancer Study Group includes Albert Einstein College of Medicine/Montefiore Medical Center (Myrna Ben-Yishay, Janice P. Dutcher, Susan J. Gross, Carolyn D. Runowicz, Usha Venkatraj); Beth Israel Medical Center (Katherine Daley, Gayna Havens, Victor B. Penchaszadeh, Bert Petersen, Peter Pressman, Diana Punales-Morejon); Columbia Presbyterian Medical Center, Columbia University (Karen H. Antman, Donna Russo); Englewood Hospital and Medical Center (Sherry L. Campbell Grumet);...

Abstract

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 . We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks in families with many cases. Risks appear to be increasing with time: Breast cancer risk by age 50 among mutation carriers born before 1940 was 24%, but among those born after 1940 it was 67%. Lifetime risks of ovarian cancer were 54% for BRCA1 and 23% for BRCA2 mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. SEER Cancer Statistics Review 1973â1999 2002

2. Modifiers of risk of hereditary breast and ovarian cancer

3. Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

4. E. Levy-Lahad et al., Am. J. Hum. Genet.60, 1059 (1997).

5. The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews

Cited by 1846 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. 2D graphene-based advanced nanoarchitectonics for electrochemical biosensors: Applications in cancer biomarker detection;Biosensors and Bioelectronics;2024-04

2. Patient-reported outcomes in bilateral prophylactic mastectomy with breast reconstruction: A narrative review;The Breast;2024-02

3. A pancancer analysis of the clinical and genomic characteristics of multiple primary cancers;Scientific Reports;2024-01-29

4. Factors associated with the onset and survival of subsequent primary breast cancer in female non‐metastatic breast cancer survivors;Precision Medical Sciences;2024-01-07

5. PARPis response and outcome of ovarian cancer patients with BRCA1/2 germline mutation and a history of breast cancer;Journal of Gynecologic Oncology;2024