Oral mycobiota and pancreatic ductal adenocarcinoma

Author:

Wei Ailin,Zhao Huiling,Cong Xue,Wang Linyao,Chen Yiyang,Gou Juxiang,Hu Ziyi,Hu Xiuying,Tian Yali,Li Ka,Deng Yufeng,Zuo HaojiangORCID,Fu Mei RosemaryORCID

Abstract

AbstractEarly detection of pancreatic ductal adenocarcinoma (PDAC) is essential for survival. Preliminary research demonstrated significant associations between structural alternation of mycobiota and PDAC. In this study, we investigated the associations between oral mycobiota and PDAC. We further explored mycobiota biomarkers for PDAC detection. We enrolled 34 PDAC patients and 35 matched healthy controls from West China hospital in Southwest China. Demographic data, clinical information, and salivary samples were collected. Mycobiota characteristics were defined using Internal Transcribed Spacer (ITS) ribosomal RNA sequencing. We found that the PDAC patients had significant increase in fungal abundance (P < 0.001) and significant decrease in fungal diversity (P < 0.001) in comparison to the healthy controls. A higher abundance of Basidiomycota and Unclassifed_p_Ascomycota was associated with an increased risk of PDAC. With each increase of abundance of g__unclassified_k__Fungi and g__unclassified_p__Ascomycota in PDAC patients, the risk of pancreatic cancer increased by 1.359 odds and 1.260 odds, respectively. Aspergillus (AUC = 0.983, 95% CI 0.951–1.000) and Cladosporium (AUC = 0.969, 95% CI 0.921–1.000) achieved high classification powers to distinguish PDAC patients from the healthy controls. The rapid, inexpensive tests of ITS1 sequencing of mycobiota and PCR detection of potential fungal biomarkers make it promising for the clinical practice to use oral microbes for PDAC early detection and prevention. Results of our study provide evidence that salivary mycobiota may provide insights into cancer risk, prevention, and detection.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Gut fungal, friends or foes? Exploring the role of mycobiome in pancreatic cancer;IP International Journal of Comprehensive and Advanced Pharmacology;2023-11-15

2. Microbiota and mycobiota in bronchoalveolar lavage fluid of silicosis patients;Journal of Occupational Medicine and Toxicology;2023-07-10

3. Fungi and cancer;Gut;2023-05-05

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