Author:
Wang Yicheng,Yang Gang,You Lei,Yang Jinshou,Feng Mengyu,Qiu Jiangdong,Zhao Fangyu,Liu Yueze,Cao Zhe,Zheng Lianfang,Zhang Taiping,Zhao Yupei
Abstract
AbstractPancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation. Potential therapeutic and diagnostic applications of microbiomes are also discussed. For example, microbiomes may serve as diagnostic markers for pancreatic cancer, and may also play an important role in determining the efficacies of treatments such as chemo- and immunotherapies. Future studies will provide additional insights into the various roles of microbiomes in pancreatic cancer.
Funder
National Natural Science Foundation of China
CAMS Innovation Fund for Medical Sciences
Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences
Natural Science Foundation of Beijing
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine
Cited by
66 articles.
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