Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine
Link
http://link.springer.com/content/pdf/10.1186/s13073-018-0523-8.pdf
Reference34 articles.
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2. Schaub MA, Boyle AP, Kundaje A, Batzoglou S, Snyder M. Linking disease associations with regulatory information in the human genome. Genome Res. 2012;22:1748–59. https://doi.org/10.1101/gr.136127.111 .
3. Jones L, Lambert J-C, Wang L-S, Choi S-H, Harold D, Vedernikov A, et al. Convergent genetic and expression data implicate immunity in Alzheimer’s disease. Alzheimer’s Dement. 2015;11:658–71. https://doi.org/10.1016/j.jalz.2014.05.1757 .
4. Gjoneska E, Pfenning AR, Mathys H, Quon G, Kundaje A, Tsai L-H, et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease. Nature. 2015;518:365–9. https://doi.org/10.1038/nature14252 .
5. Gagliano SA, Pouget JG, Hardy J, Knight J, Barnes MR, Ryten M, et al. Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases. Ann Clin Transl Neurol. 2016;3:924–33. https://doi.org/10.1002/acn3.369 .
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