Convergent genetic and expression data implicate immunity in Alzheimer's disease

Author:

,Jones Lesley12,Lambert Jean‐Charles345,Wang Li‐San6,Choi Seung‐Hoan7,Harold Denise8,Vedernikov Alexey1,Escott‐Price Valentina1,Stone Timothy1,Richards Alexander1,Bellenguez Céline345,Ibrahim‐Verbaas Carla A.9,Naj Adam C.10,Sims Rebecca1,Gerrish Amy1,Jun Gyungah11127,DeStefano Anita L.7,Bis Joshua C.13,Beecham Gary W.1014,Grenier‐Boley Benjamin345,Russo Giancarlo15,Thornton‐Wells Tricia A.16,Jones Nicola1,Smith Albert V.1718,Chouraki Vincent345,Thomas Charlene1,Ikram M. Arfan1920,Zelenika Diana21,Vardarajan Badri N.11,Kamatani Yoichiro22,Lin Chiao‐Feng6,Schmidt Helena23,Kunkle Brian W.10,Dunstan Melanie L.1,Ruiz Agustin24,Bihoreau Marie‐Thérèse21,Reitz Christiane2526,Pasquier Florence427,Hollingworth Paul1,Hanon Olivier28,Fitzpatrick Annette L.1329,Buxbaum Joseph D.303132,Campion Dominique33,Crane Paul K.34,Becker Tim35,Gudnason Vilmundur1718,Cruchaga Carlos36,Craig David37,Amin Najaf38,Berr Claudine39,Lopez Oscar L.40,De Jager Philip L.4142,Deramecourt Vincent327,Johnston Janet A.37,Evans Denis43,Lovestone Simon44,Letteneur Luc45,Kornhuber Johanes46,Tárraga Lluís24,Rubinsztein David C.47,Eiriksdottir Gudny18,Sleegers Kristel4849,Goate Alison M.36,Fiévet Nathalie35,Huentelman Matthew J.50,Gill Michael51,Emilsson Valur1718,Brown Kristelle52,Kamboh M. Ilyas5354,Keller Lina55,Barberger‐Gateau Pascale45,McGuinness Bernadette37,Larson Eric B.345657,Myers Amanda J.58,Dufouil Carole45,Todd Stephen37,Wallon David33,Love Seth59,Kehoe Pat59,Rogaeva Ekaterina60,Gallacher John61,St George‐Hyslop Peter6062,Clarimon Jordi6364,Lleò Alberti6364,Bayer Anthony61,Tsuang Debby W.65,Yu Lei66,Tsolaki Magda67,Bossù Paola68,Spalletta Gianfranco68,Proitsi Petra44,Collinge John69,Sorbi Sandro7071,Sanchez Garcia Florentino72,Fox Nick73,Hardy John74,Deniz Naranjo Maria Candida72,Razquin Cristina75,Bosco Paola76,Clarke Robert77,Brayne Carol78,Galimberti Daniela79,Mancuso Michelangelo80,Moebus Susanne81,Mecocci Patrizia82,Zompo Maria83,Maier Wolfgang84,Hampel Harald85,Pilotto Alberto86,Bullido Maria878889,Panza Francesco90,Caffarra Paolo9192,Nacmias Benedetta7071,Gilbert John R.1014,Mayhaus Manuel93,Jessen Frank84,Dichgans Martin94,Lannfelt Lars95,Hakonarson Hakon96,Pichler Sabrina93,Carrasquillo Minerva M.97,Ingelsson Martin95,Beekly Duane98,Alavarez Victoria99,Zou Fanggeng97,Valladares Otto6,Younkin Steven G.97,Coto Eliecer99,Hamilton‐Nelson Kara L.10,Mateo Ignacio100,Owen Michael J.1,Faber Kelley M.101,Jonsson Palmi V.102,Combarros Onofre100,O'Donovan Michael C.1,Cantwell Laura B.6,Soininen Hilkka103104,Blacker Deborah105106,Mead Simon69,Mosley Thomas H.107,Bennett David A.66107,Harris Tamara B.108,Fratiglioni Laura109110,Holmes Clive111,Bruijn Renee F.A.G.112,Passmore Peter37,Montine Thomas J.113,Bettens Karolien4849,Rotter Jerome I.114,Brice Alexis115116,Morgan Kevin52,Foroud Tatiana M.101,Kukull Walter A.117,Hannequin Didier33,Powell John F.44,Nalls Michael A.118,Ritchie Karen39,Lunetta Kathryn L.7,Kauwe John S.K.47,Boerwinkle Eric119120,Riemenschneider Matthias121,Boada Mercè122,Hiltunen Mikko103104,Martin Eden R.1014,Pastor Pau123124,Schmidt Reinhold125,Rujescu Dan126,Dartigues Jean‐François45127,Mayeux Richard2526,Tzourio Christophe128,Hofman Albert1920,Nöthen Markus M.129,Graff Caroline110130,Psaty Bruce M.13131,Haines Jonathan L.16132,Lathrop Mark2122133,Pericak‐Vance Margaret A.1014,Launer Lenore J.108,Farrer Lindsay A.11127134135,Duijn Cornelia M.38,Van Broeckhoven Christine4849,Ramirez Alfredo136,Schellenberg Gerard D.6,Seshadri Sudha135,Amouyel Philippe34527,Williams Julie1,Holmans Peter A.1,

Affiliation:

1. Institute of Psychological Medicine and Clinical Neurosciences Cardiff University, Hadyn Ellis Building Maindy Road Cardiff CF24 4HQ

2. Department of Medicine (Geriatrics) University of Mississippi Medical Center Jackson MS 39216 USA

3. Inserm U744 Lille 59000 France

4. Université Lille 2 Lille 59000 France

5. Institut Pasteur de Lille Lille 59000 France

6. Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA 19104 USA

7. Department of Biostatistics Boston University School of Public Health Boston MA 02118 USA

8. Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity Centre for Health Sciences St James's Hospital Dublin 8

9. Department of Epidemiology, Clinical Genetics and Neurology Erasmus MC University Medical Center Rotterdam 3015 CE The Netherlands

10. The John P. Hussman Institute for Human Genomics University of Miami Miami FL 33124 USA

11. Department of Medicine (Biomedical Genetics) Boston University School of Medicine Boston MA 02218 USA

12. Department of Ophthalmology Boston University School of Medicine Boston MA 02215 USA

13. Cardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA 98101 USA

14. Dr. John T. Macdonald Foundation Department of Human Genetics University of Miami Miami FL 33124 USA

15. Functional Genomics Center Zurich 8038 Switzerland

16. Department of Molecular Physiology and Biophysics Vanderbilt University Nashville TN 37212 USA

17. University of Iceland Faculty of Pharmaceutical Sciences Reykjavik 525-4000 Iceland

18. Icelandic Heart Association Kopavogur 525-4000 Iceland

19. Departments of Epidemiology, Neurology and Radiology Erasmus MC University Medical Center Rotterdam 3015 CE The Netherlands

20. Netherlands Consortium for Healthy Aging Leiden The Netherlands

21. Centre National de Genotypage Institut Genomique, Commissariat à l'énergie Atomique Evry 91300 France

22. Fondation Jean Dausset- CEPH Paris 75010 France

23. Institute for Molecular Biology and Biochemistry Medical University of Graz Graz 8010 Austria

24. Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades Barcelona 8029 Spain

25. Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology Columbia University New York NY New York 10027 USA

26. Gertrude H. Sergievsky Center, Columbia University, Department of Neurology Columbia University New York NY 10027 USA

27. Centre Hospitalier Régional Universitaire de Lille Lille 59000 France

28. UMR 894 Inserm, Faculté de Médecine Université Paris Descartes Paris 75014 France

29. Departments of Epidemiology and Global Health University of Washington Seattle WA 98101 USA

30. Department of Neuroscience Mount Sinai School of Medicine New York NY 10027 USA

31. Department of Psychiatry Mount Sinai School of Medicine New York NY 10027 USA

32. Departments of Genetics and Genomic Sciences Mount Sinai School of Medicine New York NY 10027 USA

33. INSERM U614, Faculté de Médecine Centre Hospitalier du Rouvray Rouen 76000 France

34. Department of Medicine University of Washington Seattle WA 98195 USA

35. German Center for Neurodegenerative Diseases (DZNE, Bonn) and Institute for Medical Biometry, Informatics and Epidemiology University of Bonn Bonn Germany 53113

36. Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration Washington University School of Medicine St. Louis MO 98122 USA

37. Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast BT7 1NN Belfast UK

38. Department of Epidemiology Erasmus MC University Medical Center Rotterdam 3015 CE The Netherlands

39. INSERM U888, Hôpital La Colombière Montpellier 34000 France

40. Departments of Neurology University of Pittsburgh School of Medicine Pittsburgh PA 15213 USA

41. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry Brigham and Women's Hospital and Harvard Medical School Boston MA 02215 USA

42. Program in Medical and Population Genetics Broad Institute Boston MA 02215 USA

43. Rush Institute for Healthy Aging Department of Internal Medicine, Rush University Medical Center Chicago IL 60612 USA

44. King's College London, Institute of Psychiatry Department of Neuroscience De Crespigny Park, Denmark, Hill London SE5

45. Inserm U897 Victor Segalen University F-33076 Bordeaux 33000 France

46. Department of Psychiatry and Psychotherapy Friedrich-Alexander-University Erlangen-Nuremberg Germany

47. Cambridge Institute for Medical Research University of Cambridge Cambridge CB2 OXY UK

48. Neurodegenerative Brain Diseases Group Department of Molecular Genetics, VIB Antwerp 2000 Belgium

49. Laboratory of Neurogenetics, Institute Born-Bunge University of Antwerp Antwerp 2000 Belgium

50. Neurogenomics Division Translational Genomics Research Institute Phoenix AZ 85004 USA

51. Mercer's Institute for Research on Aging St. James Hospital and Trinity College Dublin Dublin 8 Ireland

52. Institute of Genetics, Queen's Medical Centre University of Nottingham NG7 2UH Nottingham UK

53. Department of Human Genetics University of Pittsburgh Pittsburgh PA 15213 USA

54. Alzheimer's Disease Research Center University of Pittsburgh Pittsburgh PA 15213 USA

55. Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm 17177 Sweden

56. Group Health Research Institute Group Health Seattle WA 98195 USA

57. Group Health Research Institute Group Health Seattle WA USA

58. Department of Psychiatry and Behavioral Sciences Miller School of Medicine, University of Miami Miami FL 33124 USA

59. University of Bristol Clinical Neurosciences, Level 1 Learning and Research Building BS10 5NB Bristol

60. Tanz Centre for Research in Neurodegenerative Disease University of Toronto Toronto ON M5S 1A1 Canada

61. Institute of Primary Care and Public Health Cardiff University, Neuadd Meirionnydd, University Hospital of Wales Heath Park Cardiff CF14 4XN UK

62. Cambridge Institute for Medical Research and Department of Clinical Neurosciences University of Cambridge Cambridge CB2 1TN UK

63. Neurology Department, IIB Sant Pau, Sant Pau Hospital Universitat Autònoma de Barcelona Barcelona 08026 Spain

64. Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED) Barcelona Spain

65. Department of Psychiatry and Behavioral Sciences University of Washington Seattle WA 98195 USA

66. Department of Neurological Sciences Rush University Medical Center Chicago IL 60612 USA

67. Aristotle University of Thessaloniki Despere 3 Thessaloniki 54621 Greece

68. Clinical and Behavioral Neurology Fondazione Santa Lucia Roma 00142 Italy

69. MRC Prion Unit, Department of Neurodegenerative Disease UCL Institute of Neurology London WC1N 3BG UK

70. Department of Neurological and Psychiatric Sciences University of Florence Florence 50121 Italy

71. Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE University of Florence Florence Italy

72. Department of Immunology Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria 35012 Las Palmas Spain

73. Dementia Research Centre, Department of Neurodegenerative Disease UCL Institute of Neurology London WC1N 3BG UK

74. Department of Molecular Neuroscience and Reta Lilla Weston Laboratories Institute of Neurology London WC1N 3BG UK

75. Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research University of Navarra School of Medicine Pamplona 28023 Spain

76. IRCCS Associazione Oasi Maria SS Troina 94018 Italy

77. Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit University of Oxford Oxford OX1 2JD UK

78. Cognitive Function and Ageing Study (CFAS), Institute of Public Health University of Cambridge Cambridge CB2 1TN UK

79. University of Milan, Fondazione Cà Granda IRCCS Ospedale Policlinico Milan 20122 Italy

80. Neurological Clinic University of Pisa 56126 Pisa Italy

81. Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology University Hospital Essen, University Duisburg-Essen Essen 45141 Germany

82. Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine University of Perugia Perugia 06100 Italy

83. Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences University of Cagliari Cagliari 09123 Italy

84. Department of Psychiatry and Psychotherapy University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn) Bonn 53113 Germany

85. Université Pierre et Marie Curie, Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer Paris France

86. Gerontology and Geriatrics Research Laboratory I.R.C.C.S. Casa Sollievo della Sofferenza San Giovanni Rotondo (FG) 71013 Italy

87. Centro de Biología Molecular Severo Ochoa (CSIC-UAM) Madrid 28046 Spain

88. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) Madrid Spain

89. Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz) Madrid Spain

90. Departement of Geriatrics, Center for Aging Brain University of Bari Bari 70121 Italy

91. Department of Neuroscience-University of Parma Parma 43100 Italy

92. Center for Cognitive Disorders AUSL Parma Italy

93. Dept. Of Psychiatry University Hospital 66424 Homburg Saarland

94. Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich Germany and German Center for Neurodegenerative Diseases (DZNE, Munich) Munich 80336 Germany

95. Dept. of Public Health/Geriatrics Uppsala University Uppsala 75312 Sweden

96. Center for Applied Genomics Children's Hospital of Philadelphia Philadelphia PA 19104 USA

97. Department of Neuroscience Mayo Clinic Jacksonville FL 32224 USA

98. National Alzheimer's Coordinating Center University of Washington Seattle WA 98195 USA

99. Genetica molecular-Huca-Oviedo Oviedo 33006 Spain

100. Neurology Service and CIBERNED “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV) Santander 39005 Spain

101. Department of Medical and Molecular Genetics Indiana University Indianapolis IN 46202 USA

102. Landspitali University Hospital Reykjavik 543-1000 Iceland

103. Institute of Clinical Medicine - Neurology University of Eastern Finland Kuopio 70211 Finland

104. Department of Neurology Kuopio University Hospital FIN-70211 Kuopio Finland

105. Department of Epidemiology Harvard School of Public Health Boston MA 02115 USA

106. Department of Psychiatry Massachusetts General Hospital/Harvard Medical School Boston MA 02115 USA

107. Rush Alzheimer's Disease Center Rush University Medical Center Chicago IL 60612 USA

108. Laboratory of Epidemiology, Demography, and Biometry National Institute of Health Bethesda MD 20892 USA

109. Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm 11418 Sweden

110. Dept Geriatric Medicine, Genetics Unit Karolinska University Hospital Huddinge S-14186 Stockholm

111. Division of Clinical Neurosciences, School of Medicine University of Southampton Southampton SO17 1BJ UK

112. Departments of Neurology and Epidemiology Erasmus MC University Medical Center Rotterdam 3015 CE The Netherlands

113. Department of Pathology University of Washington Seattle WA 98195 USA

114. Medical Genetics Institute, Cedars-Sinai Medical Center Los Angeles CA 90048 USA

115. CRicm-UMRS975 Paris France

116. AP-HP, Hôpital de la Pitié-Salpêtrière Paris 75013 France

117. Department of Epidemiology University of Washington Seattle WA 98195 USA

118. Laboratory of Neurogenetics, Intramural Research Program National Institute on Aging Bethesda MD 20892 USA

119. Human Genome Sequencing Center Baylor College of Medicine Houston TX 77030 USA

120. Human Genetics Center and Div. of Epidemiology University of Texas Health Sciences Center at Houston Houston TX 77030 USA

121. Department of Psychiatry University Hospital 66424 Homburg Saarland

122. Memory Clinic of Fundació ACE Institut Català de Neurociències Aplicades Barcelona 8029 Spain

123. Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research and Department of Neurology Clínica Universidad de Navarra, University of Navarra School of Medicine Pamplona Spain

124. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Spain

125. Department of Neurology Medical University of Graz Graz 8010 Austria

126. Department of Psychiatry University of Munich, Munich and University of Halle Halle 80336 Germany

127. Centre de Mémoire de Ressources et de Recherche de Bordeaux CHU de Bordeaux Bordeaux France

128. Inserm U708 Victor Segalen University F-33076 Bordeaux 33000 France

129. Institute of Human Genetics, Department of Genomics, Life and Brain Center University of Bonn and German Center for Neurodegenerative Diseases (DZNE, Bonn) Bonn 53113 Germany

130. Karolinska Institutet Dept Neurobiology, Care Sciences and Society, KIADRC Novum floor 5, S14186 Stockholm 17177 Solna Sweden

131. Departments of Epidemiology and Health Services University of Washington Seattle WA USA

132. Vanderbilt Center for Human Genetics Research Vanderbilt University Nashville TN 37212 USA

133. McGill University and Génome Québec Innovation Centre Montreal Canada

134. Department of Epidemiology Boston University School of Public Health Boston MA 02118 USA

135. Department of Neurology Boston University School of Medicine Boston MA 02215 USA

136. Department of Psychiatry and Psychotherapy and Institute of Human Genetics University of Bonn Bonn 53113 Germany

Funder

Wellcome Trust

Medical Research Council

Alzheimer’s Research UK

National Institutes of Health

National Institute on Aging

Fédération pour la Recherche sur le Cerveau

Labex

Alzheimer's Association

Alzheimer's Research UK

Welsh Assembly Government

Erasmus Medical Center and Erasmus University

French National Foundation on Alzheimer's Disease and Related Disorders

Centre National de Génotypage

Institut Pasteur de Lille

FRC

Rotary

LABEX

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Developmental Neuroscience,Health Policy,Epidemiology

Cited by 178 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3