Author:
Chen Shih-Yuan,Chen Ta-Fu,Lai Liang-Chuan,Chen Jen-Hau,Sun Yu,Wen Li-Li,Yip Ping-Keung,Chu Yi-Min,Chen Yen-Ching
Abstract
Abstract
Background
Interleukin 6 (IL-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in Alzheimer's disease (AD) brain. However, previous studies relating IL-6 genetic polymorphisms to AD included few and unrepresentative single nucleotide polymorphisms (SNPs) and the results were inconsistent.
Methods
This is a case-control study. A total of 266 patients with AD, aged≧65, were recruited from three hospitals in Taiwan (2007-2010). Controls (n = 444) were recruited from routine health checkups and volunteers of the hospital during the same period of time. Three common IL-6 haplotype-tagging SNPs were selected to assess the association between IL-6 polymorphisms and the risk of late-onset AD (LOAD).
Results
Variant carriers of IL-6 rs1800796 and rs1524107 were significantly associated with a reduced risk of LOAD [(GG + GC vs. CC): adjusted odds ratio (AOR) = 0.64 and (CC + CT vs. TT): AOR = 0.60, respectively]. Haplotype CAT was associated with a decreased risk of LOAD (0 and 1 copy vs. 2 copies: AOR = 0.65, 95% CI = 0.44-0.95). These associations remained significant in ApoE e4 non-carriers only. Hypertension significantly modified the association between rs2069837 polymorphisms and the risk of LOAD (p
interaction = 0.03).
Conclusions
IL-6 polymorphisms are associated with reduced risk of LOAD, especially in ApoE e4 non-carriers. This study identified genetic markers for predicting LOAD in ApoE e4 non-carriers.
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology,Immunology,General Neuroscience
Reference37 articles.
1. Alzheimer's Association: 2010 Alzheimer's Disease Facts and Figures. Alzheimer's & Dementia.
[http://www.alz.org/alzheimers_disease_facts_figures.asp?type=homepage]
2. Fuh JL, Wang SJ: Dementia in Taiwan: past, present, and future.
Acta Neurol Taiwan 2008, 17:153–161.
3. Gadient RA, Otten UH: Interleukin-6 (IL-6)--a molecule with both beneficial and destructive potentials.
Prog Neurobiol 1997, 52:379–390.
4. Heyser CJ, Masliah E, Samimi A, Campbell IL, Gold LH: Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain.
Proc Natl Acad Sci USA 1997, 94:1500–1505.
5. Castell JV, Andus T, Kunz D, Heinrich PC: Interleukin-6: the major regulator of acute-phase protein synthesis in man and rat.
Ann NY Acad Sci 1989, 557:87–99.
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