Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif “RRQRRL” are critical for fusogenic activity

Author:

Wang Yanhong,Bi Youkun,Yu Wanqi,Wei Ning,Wang Wenbin,Wei Qiaolin,Wang Xinglong,Zhang Shuxia,Yang Zengqi,Xiao Sa

Funder

National Natural Science Fundation of China

Faculty Support Fund of the Northwest A&F University

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

Reference36 articles.

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2. Lamb RA, Parks GD. Paramyxoviridae: the viruses and their replication. In: Knipe DM, Howley PM, editors. Fields virology. 5th ed. Philadelphia: Wolters Kluwer-Lippincott Williams & Wilkins; 2007. p. 1449–96.

3. Mirza AM, Deng R, Iorio RM. Site-directed mutagenesis of a conserved hexapeptide in the paramyxovirus hemagglutinin-neuraminidase glycoprotein: effects on antigenic structure and function. J Virol. 1994;68(8):5093–9.

4. Lamb RA, Kolakofsky D. Paramyxoviridae: the viruses and their replication. In: Knipe DM, Howley PM, editors. Fundamental virology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 689–724.

5. Nagai Y, Klenk HD, Rott R. Proteolytic cleavage of the viral glycoproteins and its significance for the virulence of Newcastle disease virus. Virology. 1976;72(2):494–508.

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