Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis

Author:

Kamdar Shivani N.,Ho Linh T.,Kron Ken J.,Isserlin Ruth,van der Kwast Theodorus,Zlotta Alexandre R.,Fleshner Neil E.,Bader Gary,Bapat BharatiORCID

Funder

The Bill and Kathleen Troost Innovation Grant of the Canadian Cancer Society

University of Toronto Fellowship

Lorne F. Lambier, Q.C. Scholarship

OSOTF Studentship at Mount Sinai Hospital

Paul Starita Graduate Student Fellowship

Research Training Centre Travel Award at Mount Sinai Hospital

Laboratory Medicine and Pathobiology (LMP) Travel Award at the University of Toronto

Ontario Graduate Scholarship – Faculty of Medicine at University of Toronto

Scace Graduate Fellowship in Prostate Cancer Research

George Sidney Brett Memorial Fund

Frank Fletcher Memorial Fund

Research Training Centre (RTC) Travel Award at Mount Sinai Hospital

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Developmental Biology,Genetics,Molecular Biology

Reference59 articles.

1. Van Vlodrop IJ, Niessen HE, Derks S, Baldewijns MM, van Criekinge W, Herman JG, et al. Analysis of promoter CpG island hypermethylation in cancer: location, location, location! Clin Cancer Res. 2011. doi: 10.1158/1078-0432.CCR-10-3394 .

2. Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene. 2002;21(35):5427–40.

3. Sproul D, Kitchen RR, Nestor CE, Dixon JM, Sims AH, Harrison DJ, et al. Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns. Genome Biol. 2012. doi: 10.1186/gb-2012-13-10-r84 .

4. Esteller M, Herman JG. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol. 2002;196(1):1–7.

5. Vilain A, Vogt N, Dutrillaux B, Malfoy B. DNA methylation and chromosome instability in breast cancer cell lines. FEBS Lett. 1999;460(2):231–4.

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