Author:
Sarr Serigne O,Perrotey Sylvie,Fall Ibrahima,Ennahar Saïd,Zhao Minjie,Diop Yérim M,Candolfi Ermanno,Marchioni Eric
Abstract
Abstract
Background
With the aim of discovering new natural active extracts against malaria parasites, Icacina senegalensis was selected after an ethnopharmacological survey conducted on plants used in traditional malaria treatment in Senegal.
Methods
Different concentrations of the plant extract and fractions were tested on synchronized Plasmodium falciparum cultures at the ring stage using the parasite lactate dehydrogenase assay. Their haemolytic activity and in vitro cytoxicity were evaluated. The chromatographic profiles of active fractions were also established.
Results
The plant extract and fractions revealed anti-plasmodial activity (IC50 < 5 μg/mL) with no toxicity (Selectivity indexes >10). The dichloromethane fraction showed stronger anti-plasmodial activity than the total extract.
Conclusion
Anti-plasmodial activity and toxicity of I. senegalensis are reported for the first time and showed promising results in malaria field research.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Parasitology
Reference37 articles.
1. WHO: World Malaria Report. 2010, [http://www.rbm.who.int]
2. Trape JF, Pison G, Spiegel A, Enel C, Rogier C: Combating malaria in Africa. Trends Parasitol. 2002, 18: 224-230. 10.1016/S1471-4922(02)02249-3.
3. Benoît-Vical F: Ethnomedicine in malaria treatment. Idrugs. 2005, 8: 45-52.
4. Sarr SO, Ciss M, Fall D, Diedhiou A, Diop YM, Diop A, Smine A, Ndiaye B: Contrôle de la qualité d'une combinaison libre d'amodiaquine et d'artésunate. Ann Fals Exp Chim. 2008, 968: 40-45.
5. Willcox ML, Bodeker G: Plant-based malaria control: research initiative on traditional antimalarial methods. Parasitol Today. 2000, 16: 220-221. 10.1016/S0169-4758(00)01678-1.
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