Author:
Uings Iain,Puxeddu Ilaria,Temkin Vladislav,Smith Susan J,Fattah Dilniya,Ray Keith P,Levi-Schaffer Francesca
Abstract
Summary
Background
TNF-alpha is an important mediator in allergy also for its effects on eosinophils.
Methods
The effect of dexamethasone on TNF-alpha induced eosinophils survival, degranulation (ECP), cytokines release (IL-8, GM-CSF) and adhesion to VCAM-1, ICAM-1 and IgG coated wells (EPO release) were evaluated.
Results
The drug inhibited IL-8 and GM-CSF production, but not viability, degranulation or adhesion in human peripheral blood eosinophils.
Conclusion
These results indicate that part of the activity of glucocorticosteroids on eosinophils may be mediated by their ability to inhibit cytokine secretion that in turn is important for the perpetuation of the allergic inflammation.
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Immunology,Immunology and Allergy
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