Author:
Hong Zhang,Jing Ren,Hui Li,Kang Xu,Chunmei Zhang,Yang Wang,Baojian Zhou,Xin Ding,Xiaoping Yin
Abstract
Abstract
Objective
To understand the occurrence of atopic dermatitis (AD) in children aged 2 years on exposure to maternal group B streptococcus (GBS) antibiotic prophylaxis (IAP).
Design
Retrospective cohort study of 2909 mother–child pairs.
Setting
Taixing People’s Hospital in Eastern China.
Participants
Term infants born 2018–2019, followed longitudinally from birth to 2 years.
Exposures
The GBS-IAP was defined as therapy with intravenous penicillin G or ampicillin or cefazolin ≥ 4 h prior to delivery to the mother. Reference infants were defined as born without or with other intrapartum antibiotic exposure.
Outcomes
The logistic regression models were employed to analyze the effect of intrapartum GBS prophylaxis on AD in 2-year-old children during delivery. Analysis was a priori stratified according to the mode of delivery and adjusted for relevant covariates.
Results
The cohorts showed that preventive GBS-IAP was potentially associated with increased incidence of AD in children delivered vaginally according to logistic regression models before and after covariate-adjusted treatment (OR: 6.719,95% CI: 4.730–9.544,P < 0.001;aOR: 6.562,95% CI: 4.302–10.008, P < 0.001).
Conclusion
Prophylactic treatment of intrapartum GBS may raise the risk of AD in vaginally delivered children. These findings highlight the need to better understand the risk between childhood AD and current GBS-IAP intervention strategies.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
Cited by
4 articles.
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