Author:
Fadeyi Saudat Adamson,Fadeyi Olugbeminiyi O,Adejumo Adedeji A,Okoro Cosmas,Myles Elbert Lewis
Abstract
Abstract
Background
Plants that are used as traditional medicine represent a relevant pool for selecting plant candidates that may have anticancer properties. In this study, the ethnomedicinal approach was used to select several medicinal plants native to Nigeria, on the basis of their local or traditional uses. The collected plants were then evaluated for cytoxicity.
Methods
The antitumor activity of methanolic extracts obtained from 24 of the selected plants, were evaluated in vitro on five human cancer cell lines.
Results
Results obtained from the plants screened indicate that 18 plant extracts of folk medicine exhibited promising cytotoxic activity against human carcinoma cell lines. Erythrophleum suaveolens (Guill. & Perr.) Brenan was found to demonstrate potent anti-cancer activity in this study exhibiting IC50 = 0.2-1.3 μg/ml.
Conclusions
Based on the significantly potent activity of some plants extracts reported here, further studies aimed at mechanism elucidation and bio-guided isolation of active anticancer compounds is currently underway.
Publisher
Springer Science and Business Media LLC
Subject
Complementary and alternative medicine,General Medicine
Reference38 articles.
1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 2008, 58: 71-96. 10.3322/CA.2007.0010.
2. Farnsworth NR: Screening plants for new medicines. Chapter 9 in Biodiversity. Edited by: Wilson EO. 1988, Washington D.C: National Academy Press
3. Kim J, Park EJ: Cytotoxic anticancer candidates from natural resources. Curr Med Chem Anti-Canc Agents. 2002, 2: 485-537. 10.2174/1568011023353949.
4. Mann J: Natural products in cancer chemotherapy: past, present and future. Nat Rev Cancer. 2002, 2: 143-148.
5. Grabley S, Thiericke R: Bioactive agents from natural sources: trends in discovery and application. Adv Biochem Engin Biotechnol. 1999, 64: 104-154.
Cited by
82 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献