Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma

Author:

Wong Deborah JL,Robert Lidia,Atefi Mohammad S,Lassen Amanda,Avarappatt Geetha,Cerniglia Michael,Avramis Earl,Tsoi Jennifer,Foulad David,Graeber Thomas G,Comin-Anduix Begonya,Samatar Ahmed,Lo Roger S,Ribas Antoni

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Molecular Medicine

Reference35 articles.

1. Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O’Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA: Improved survival with vemurafenib in melanoma with braf V600e mutation. N Engl J Med. 2011, 364: 2507-2516.

2. Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, Kudchadkar R, Burris HA, Falchook G, Algazi A, Lewis K, Long GV, Puzanov I, Lebowitz P, Singh A, Little S, Sun P, Allred A, Ouellet D, Kim KB, Patel K, Weber J: Combined braf and Mek inhibition in melanoma with braf V600 mutations. N Engl J Med. 2012, 367: 1694-1703.

3. Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH, Kaempgen E, Martin-Algarra S, Karaszewska B, Mauch C, Chiarion-Sileni V, Martin AM, Swann S, Haney P, Mirakhur B, Guckert ME, Goodman V, Chapman PB: Dabrafenib in braf-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012, 380: 358-365.

4. Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, Hussain J, Reis-Filho JS, Springer CJ, Pritchard C, Marais R: Kinase-dead braf and oncogenic Ras cooperate to drive tumor progression through craf. Cell. 2010, 140: 209-221.

5. Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N: Raf inhibitors transactivate Raf dimers and Erk signalling in cells with wild-type braf. Nature. 2010, 464: 427-430.

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