Author:
Nguyen Trong Nguyen,Lee Yeong-Geun,Kim Hyoung-Geun,Yoon Dahye,Jeong Jin Tae,Lee Dae Young,Baek Nam-In
Abstract
AbstractRepeated column chromatography using Sephadex LH-20, silica gel (SiO2), and octadecyl SiO2 (ODS) as well as preparative HPLC column chromatography led to isolation of a new dibenzocyclooctadiene lignan along with four known ones, gomisin L2 (1), L1 (2), M1 (3), and M2 (4). Their chemical structures were fixed based on MS, IR, and NMR data analyses. In addition, the stereochemistry of atropisomers, the absolute configuration of the axial chirality in a biphenyl structure, was confirmed by a CD experiment. The new lignan was named gomisin M3 (5).
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,General Biochemistry, Genetics and Molecular Biology
Reference27 articles.
1. Flora of China Editorial Committee (1996) Flora of China. Science Press, Beijing, p 252
2. Chinese Pharmacopoeia Commission (2005) Pharmacopoeia of the People’s Republic of China, People’s Medical Publishing House, Beijing, p 109.
3. Richardson MD, Peterson JR, Clark AM (1992) Bioactivity screenings of plants selected on the basis of folkloric use or presence of lignans in a family. Phytotherapy Res 6:274–278
4. Han HJ, Jung UJ, Kim HJ, Moon BS, Cho SJ, Park YB, Lee DG, Choi MS (2015) Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice. Nutr Res Pract 9:227–234
5. Liu KT, Lesca P (1982) Pharmacological properties of dibenzo[a, c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids. Chem Biol Interact 41:39–47
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献