Author:
Choi Sung-Kyu,Lee Yeong-Geun,Wang Rong Bo,Kim Hyoung-Geun,Yoon Dahye,Lee Dae Young,Kim Yeon-Ju,Baek Nam-In
Abstract
AbstractRepeated chromatographic separations of the EtOAc fraction of Schisandra chinensis fruits on silica gel, octadecyl silica gel, and Sephadex LH-20 led to the isolation and identification of seven dibenzocyclooctadiene lignans (1–7). The NMR data reported in the literature for angeloyl gomisin H (5) were shown to be incorrect. We unambiguously identified the compounds based on detailed analysis of the 1D and 2D NMR data, especially from HMBC and NOESY experiments. In addition, MTT assays and cell viability experiments verified the cytotoxicity of the isolated dibenzocyclooctadiene lignans against the human cancer cell lines AGS, HeLa, and HT-29.
Funder
Rural Development Aadministration
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,General Biochemistry, Genetics and Molecular Biology
Reference33 articles.
1. Lee SI (1981) Herbal Medicine. Korea, SooSeoWon, p 172
2. An RB, Oh SH, Jeong GS, Kim YC (2006) Gomisin J with protective effect against t-BHP-induced oxidative damage in HT22 cells from Schizandra chinensis. Nat Prod Sci 12:134–137
3. Shin SY, Lee J, Gil HN, Jung YJ, Kim GL, Kang GH, Lim Y (2018) Schisandra chinensis inhibiting TGFβ-induced activation of hepatic stellate cells. Appl Biol Chem 61:607–616
4. Zhu L, Li B, Liu X, Huang G, Meng X (2015) Purification of six lignans from the stems of Schisandra chinensis by using high-speed counter-current chromatography combined with preparative high-performance liquid chromatography. Food Chem 186:146–152
5. Nakajima K, Taguchi H, Ikeya Y, Endo T, Yosioka I (1983) Constituents of Schizandra chinensis Baill. XIII. Quantitative analysis of lignans in the fruits of Schizandra chinensis Baill. by high performance liquid chromatography. J Pharm Soc Jpn 103:743–749
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献