Affiliation:
1. School of Chemical Engineering Hanoi University of Science and Technology Hanoi 100000 Vietnam
2. Intellectual Property Office of Vietnam Hanoi 100000 Vietnam
3. Institute of Ecology and Biological Resources (IEBR) Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Caugiay Hanoi 100000 Vietnam
4. College of Pharmacy Thanh Do University, Kim Chung, Hoai Duc Hanoi 10000 Vietnam
5. Vietnam Military Medical University Hanoi 100000 Vietnam
Abstract
AbstractA chemical investigation of K. heteroclite led to isolation of two new dibenzocyclooctadienes (1 and 2) together with 14 known compounds (3–16) by using multiple chromatographic techniques. New compounds (1 and 2) were obtained and identified by spectroscopic methods (HR‐ESI‐MS, 1D and 2D NMR, and ECD) as well as by comparison of their experimental data with those reported in the literatures. All the isolates were evaluated for their ability to modulate TNF‐α production in lipopolysaccharide (LPS) stimulated RAW264.7 cells. Among them, compound 5 displayed the most inhibition against tumor necrosis factor (TNF)‐α production with IC50 value of 6.16±0.14 μM. Whereas, compounds (1, 3, and 6) showed the significant inhibition (IC50 values ranging from 9.41 to 14.54 μM), and compounds (2, 4, 9, 10, 13, 15, and 16) exhibited moderate inhibition (IC50 values ranging from 19.27 to 40.64 μM) toward TNF‐α production, respectively.
Funder
Trường Đại học Bách Khoa Hà Nội
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering