Affiliation:
1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Key Laboratory of Plants Resources and Chemistry of Arid Zone Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences South Beijing Road 40–1 Urumqi 830011 Xinjiang PR China
2. University of Chinese Academy of Sciences Beijing 100039 PR China
Abstract
AbstractA new monoterpene, (−)‐10‐hydroxydihydroactinidiolide (1), along with two known monoterpenes, loliolide (2) and (+)‐isololiolide (3), three known megastigmanes, 3α‐hydroxy‐5β,6β‐epoxy‐β‐ionone (4), 3α‐hydroxy‐5α,6α‐epoxy‐β‐ionone (5), and (+)‐dehydrovomifoliol (6), a eudesmane‐type sesquiterpene, 4α‐hydroxy‐4β‐methyldihydrocostol (7), a monoterpene, 8‐hydroxycarvotanacetone (8), two flavonoids, chrysoeriol (9) and apigenin (10), and a phenylpropanoid, 3‐(4‐hydroxyphenyl)‐1‐propanol (11), were isolated from the whole plant of Achillea millefolium. The structure of compound 1 was identified according to spectroscopic data of HRMS and NMR, and its absolute configuration was assigned by 13C NMR calculations with DP4+ probability analyses and ECD calculations. The absolute configuration of compound 6 was determined by ECD calculations. Compounds 3, 6, 9 and 10 could dose‐dependently inhibit the NO release in LPS‐induced RAW264.7 cells.
Funder
Natural Science Foundation of Xinjiang Uygur Autonomous Region
Science Fund for Distinguished Young Scholars of Xinjiang Autonomous Region