Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy-Reference-Cited by-同舟云学术

Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy

Published:2014-12 Issue:1 Volume:9 Page:
ISSN:1750-1172
Container-title:Orphanet Journal of Rare Diseases
language:en
Short-container-title:Orphanet J Rare Dis

Author:

Chumakov Ilya,Milet Aude,Cholet Nathalie,Primas Gwenaël,Boucard Aurélie,Pereira Yannick,Graudens Esther,Mandel Jonas,Laffaire Julien,Foucquier Julie,Glibert Fabrice,Bertrand Viviane,Nave Klaus-Armin,Sereda Michael W,Vial Emmanuel,Guedj Mickaël,Hajj Rodolphe,Nabirotchkin Serguei,Cohen Daniel

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Genetics(clinical),General Medicine

Link

http://link.springer.com/content/pdf/10.1186/s13023-014-0201-x.pdf

Reference51 articles.

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3. Fledrich R, Stassart RM, Klink A, Rasch LM, Prukop T, Haag L, Czesnik D, Kungl T, Abdelaal TAM, Keric N, Stadelmann C, Brück W, Nave K-A, Sereda MW: Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nat Med. 2014, 20: 1055-1061. 10.1038/nm.3664.

4. Nave K-A, Trapp BD: Axon-glial signaling and the glial support of axon function. Annu Rev Neurosci. 2008, 31: 535-561. 10.1146/annurev.neuro.30.051606.094309.

5. Sereda M, Griffiths I, Pühlhofer A, Stewart H, Rossner MJ, Zimmerman F, Magyar JP, Schneider A, Hund E, Meinck HM, Suter U, Nave KA: A transgenic rat model of Charcot-Marie-Tooth disease. Neuron. 1996, 16: 1049-1060. 10.1016/S0896-6273(00)80128-2.

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