Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data?

Author:

Wilson R. Alan,Li Xiao-Hong,Castro-Borges William

Funder

CAPES

Natural Science Foundation of Shanghai, China

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Parasitology

Reference115 articles.

1. Figueiredo BC, Assis NR, Morais SB, Ricci ND, Pinheiro CS, Martins VP, et al. Schistosome syntenin partially protects vaccinated mice against Schistosoma mansoni infection. PLoS Negl Trop Dis. 2014;8(8), e3107.

2. Diniz PP, Nakajima E, Miyasato PA, Nakano E, de Oliveira RM, Martins EA. Two SmDLC antigens as potential vaccines against schistosomiasis. Acta Trop. 2014;140:193–201.

3. Dias SR, Boroni M, Rocha EA, Dias TL, de Laet SD, Oliveira FM, et al. Evaluation of the Schistosoma mansoni Y-box-binding protein (SMYB1) potential as a vaccine candidate against schistosomiasis. Front Genet. 2014;5:174.

4. Neves LX, Sanson AL, Wilson RA, Castro-Borges W. What’s in SWAP? Abundance of the principal constituents in a soluble extract of Schistosoma mansoni revealed by shotgun proteomics. Parasit Vectors. 2015;8:337.

5. Aitken R, Coulson PS, Wilson RA. Pulmonary leukocytic responses are linked to the acquired immunity of mice vaccinated with irradiated cercariae of Schistosoma mansoni. J Immunol. 1988;140(10):3573–9.

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