Transmission-Blocking Vaccines against Schistosomiasis Japonica

Author:

Zumuk Chika P.12,Jones Malcolm K.13,Navarro Severine124ORCID,Gray Darren J.5,You Hong13ORCID

Affiliation:

1. Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia

2. Faculty of Medicine, The University of Queensland, Herston, QLD 4006, Australia

3. School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia

4. Centre for Childhood Nutrition Research, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4000, Australia

5. Population Health Program, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia

Abstract

Control of schistosomiasis japonica, endemic in Asia, including the Philippines, China, and Indonesia, is extremely challenging. Schistosoma japonicum is a highly pathogenic helminth parasite, with disease arising predominantly from an immune reaction to entrapped parasite eggs in tissues. Females of this species can generate 1000–2200 eggs per day, which is about 3- to 15-fold greater than the egg output of other schistosome species. Bovines (water buffalo and cattle) are the predominant definitive hosts and are estimated to generate up to 90% of parasite eggs released into the environment in rural endemic areas where these hosts and humans are present. Here, we highlight the necessity of developing veterinary transmission-blocking vaccines for bovines to better control the disease and review potential vaccine candidates. We also point out that the approach to producing efficacious transmission-blocking animal-based vaccines before moving on to human vaccines is crucial. This will result in effective and feasible public health outcomes in agreement with the One Health concept to achieve optimum health for people, animals, and the environment. Indeed, incorporating a veterinary-based transmission vaccine, coupled with interventions such as human mass drug administration, improved sanitation and hygiene, health education, and snail control, would be invaluable to eliminating zoonotic schistosomiasis.

Funder

NHMRC (National Health and Medical Research Council) of Australia Investigator Grant

Research Training Programme (RTP) Scholarship from the University of Queensland

Publisher

MDPI AG

Reference234 articles.

1. (2020). Ending the Neglect to Attain the Sustainable Development Goals: A Road Map for Neglected Tropical Diseases 2021–2030, World Health Organization.

2. World Health Organization (2023, October 01). Schistosomiasis. Available online: https://www.who.int/news-room/fact-sheets/detail/schistosomiasis.

3. Schistosomiasis in the People’s Republic of China: Prospects and challenges for the 21st century;Ross;Clin. Microbiol. Rev.,2001

4. Schistosomiasis—From immunopathology to vaccines;McManus;Semin. Immunopathol.,2020

5. The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game;Ogongo;Front. Immunol.,2022

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3