Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
Author:
Funder
Agence Nationale de la Recherche
Center of Excellence in Neurodegeneration : Bordeaux Initiative for Neurodegenerative Disorders
Multiple System Atrophy Coalition
Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1186/s40035-024-00408-x.pdf
Reference10 articles.
1. De Giorgi F, Uversky VN, Ichas F. α-synuclein fibrils as penrose machines: a chameleon in the gear. Biomolecules. 2022;12:494.
2. Shahnawaz M, Mukherjee A, Pritzkow S, Mendez N, Rabadia P, Liu X, et al. Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy. Nature. 2020;578:273–7.
3. De Giorgi F, Laferrière F, Zinghirino F, Faggiani E, Lends A, Bertoni M, et al. Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons. Sci Adv. 2020;6:eabc4364.
4. Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, et al. α-Synuclein strains target distinct brain regions and cell types. Nat Neurosci. 2020;23:21–31.
5. Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, et al. Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies. Nature. 2018;557:558–63.
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