Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons-Reference-Cited by-同舟云学术

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons

Published:2020-10-02 Issue:40 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

De Giorgi Francesca¹²³^ORCID,Laferrière Florent¹²^ORCID,Zinghirino Federica¹²⁴^ORCID,Faggiani Emilie¹²^ORCID,Lends Alons⁵^ORCID,Bertoni Mathilde⁵^ORCID,Yu Xuan⁶^ORCID,Grélard Axelle⁵^ORCID,Morvan Estelle⁷^ORCID,Habenstein Birgit⁵^ORCID,Dutheil Nathalie¹²^ORCID,Doudnikoff Evelyne¹²^ORCID,Daniel Jonathan⁸^ORCID,Claverol Stéphane⁹^ORCID,Qin Chuan⁶^ORCID,Loquet Antoine⁵^ORCID,Bezard Erwan¹²^ORCID,Ichas François¹²³^ORCID

Affiliation:

1. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France.

2. Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France.

3. INSERM, Laboratoire de Neurosciences Expérimentales et Cliniques, U-1084, Université de Poitiers, Poitiers, France.

4. Dipartimento di Scienze Biomediche e Biotecnologiche (BIOMETEC), Università degli Studi di Catania, Catania, Italia.

5. Institut de Chimie et de Biologie des Membranes et des Nano-objets, Institut Européen de Chimie et Biologie, CNRS, UMR 5248, Université de Bordeaux, Pessac, France.

6. Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China.

7. Université de Bordeaux, CNRS, INSERM, UMS3033/US001, Institut Européen de Chimie et Biologie, Pessac, France.

8. Institut des Sciences Moléculaires, CNRS, UMR 5255, Université de Bordeaux, Talence, France.

9. Plateforme de Protéomique, Université de Bordeaux, Bordeaux, France.

Abstract

Stealth α-synuclein amyloids proliferate in preparations of preformed fibrils and form aggressive self-replicating strains.

Funder

H2020 European Research Council

Swiss National Science Foundation

National Natural Science Foundation of China

Innovative Medicines Initiative

CAMS Innovation Fund for Medical Sciences

Region Nouvelle Aquitaine

SAFEA: Introduction of Overseas Talents in Cultural and Educational Sector

Del Duca foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference44 articles.

1. Cell Biology and Pathophysiology of α-Synuclein

2. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

3. α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer

4. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

5. NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

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