Single-Molecule Fingerprinting Reveals Different Growth Mechanisms in Seed Amplification Assays for Different Polymorphs of α-Synuclein Fibrils-Reference-Cited by-同舟云学术

Single-Molecule Fingerprinting Reveals Different Growth Mechanisms in Seed Amplification Assays for Different Polymorphs of α-Synuclein Fibrils

Published:2024-08-28 Issue: Volume: Page:
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Lau Derrick¹^ORCID,Tang Yuan²,Kenche Vijaya³,Copie Thomas¹^ORCID,Kempe Daryan¹,Jary Eve¹,Graves Noah J.¹,Biro Maté¹,Masters Colin L.³,Dzamko Nicolas²,Gambin Yann¹,Sierecki Emma¹^ORCID

Affiliation:

1. EMBL Australia Node for Single Molecule Science and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia

2. Brain and Mind Centre and Faculty of Medicine and Health, School of Medical Sciences, University of Sydney, Camperdown, NSW 2050, Australia

3. Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia

Funder

National Health and Medical Research Council

Michael J. Fox Foundation for Parkinson's Research

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.4c00185

Reference51 articles.

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4. Solution conditions determine the relative importance of nucleation and growth processes in -synuclein aggregation

5. High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease