Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Applied Microbiology and Biotechnology,Biophysics
Link
http://link.springer.com/content/pdf/10.1186/s13568-017-0345-x.pdf
Reference55 articles.
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2. Bai XJ, Teng D, Tian ZG, Zhu Y, Yang YL, Wang JH (2010) Contribution of bovine lactoferrin inter-lobe region to iron binding stability and antimicrobial activity against Staphylococcus aureus. Biometals 23(3):431–439
3. Breidenstein EBM, Courvalin P, Meziane-Cherif D (2015) Antimicrobial activity of plectasin NZ2114 in combination with cell wall targeting antibiotics against vana-type Enterococcus faecalis. Microb Drug Resist 21(2015):373–379
4. Brinch KS, Tulkens PM, Bambeke F, Frimodt-Moller N, Hoiby N, Kristensen HH (2010) Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin. J Antimicrob Chemother 65(2010):1720–1724
5. Brogden NK, Brogden KA (2011) Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals? Int J Antimicrob Agents 38(3):217–225
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