Biological function of Presenilin and its role in AD pathogenesis

Author:

Zhang Shuting,Zhang Mingming,Cai Fang,Song Weihong

Abstract

Abstract Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components – presenilins and their biological functions and contributions to the AD pathogenesis. The functions of presenilins are divided into γ-secretase dependent and γ-secretase independent ones. The γ-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch; the γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway, regulating calcium homeostasis and their interaction with synaptic transmission.

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neurology (clinical)

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