The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

Author:

St George-Hyslop Peter H.1,Tanzi Rudolph E.1,Polinsky Ronald J.2,Haines Jonathan L.3,Nee Linda2,Watkins Paul C.4,Myers Richard H.56,Feldman Robert G.5,Pollen Daniel7,Drachman David7,Growdon John8,Bruni Amala9,Foncin Jean-Francois10,Salmon Denise11,Frommelt Peter12,Amaducci Luigi13,Sorbi Sandro13,Piacentini Silva13,Stewart Gordon D.1,Hobbs Wendy J.1,Conneally P. Michael3,Gusella James F.1

Affiliation:

1. Neurogenetics Laboratory, Massachusetts General Hospital, and Department of Genetics and the Program m Neuroscience, Harvard Medical School, Boston, MA 02114.

2. Clinical Neuropharmacology Section, Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.

3. Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, IN 46223.

4. Integrated Genetics Inc., Framingham, MA 01701.

5. Department of Neurology, Boston University Medical School, Boston, MA 02118.

6. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114

7. Department of Neurology, University of Massachusetts Medical School, and the University of Massachusetts Medical Center, Worcester, MA 01605.

8. Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114.

9. Servizio di Neurologica, USL 17 Regione Calabria, Italy.

10. Laboratoire de Neurohistologie, Ecole Pratique des Hautes Etudes, and INSERM U 106 la Salpetriere, Paris, France.

11. Centre National de Transfusion Sanguine, Paris, France.

12. Kreiskrankenhaus Lemgo, Neurologische Abteilung, D492 Lemgo, West Germany.

13. Instituto di Malattie Nervose e Mentali, University of Florence, Florence, Italy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

1. ANDERSON, M.A., USE OF CYCLOSPORIN A IN ESTABLISHING EPSTEIN-BARR VIRUS-TRANSFORMED HUMAN-LYMPHOBLASTOID CELL-LINES, IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION 20: 856 (1984).

2. BOTSTEIN, D, CONSTRUCTION OF A GENETIC-LINKAGE MAP IN MAN USING RESTRICTION FRAGMENT LENGTH POLYMORPHISMS, AMERICAN JOURNAL OF HUMAN GENETICS 32: 314 (1980).

3. BREITNER, JCS, FAMILIAL AGGREGATION IN ALZHEIMER DEMENTIA .1. A MODEL FOR THE AGE-DEPENDENT EXPRESSION OF AN AUTOSOMAL DOMINANT GENE, JOURNAL OF PSYCHIATRIC RESEARCH 20: 31 (1986).

4. BREITNER, JCS, FAMILIAL AGGREGATION IN ALZHEIMER DEMENTIA .2. CLINICAL GENETIC-IMPLICATIONS OF AGE-DEPENDENT ONSET, JOURNAL OF PSYCHIATRIC RESEARCH 20: 45 (1986).

5. CHASE, G.A., AM J EPIDEMIOL 177: 590 (1983).

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