Author:
Malkowska Maja,Kokoszynska Katarzyna,Dymecka Magdalena,Rychlewski Leszek,Wyrwicz Lucjan S
Abstract
Abstract
Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, we propose that Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and Betaherpesvirinae UL130 originate from chemokines. Herpes simplex virus type 2 gL and human cytomegalovirus homolog (UL130) adopt a novel C chemokine-like fold, while Epstein-Barr virus gL mimics a CC chemokine structure. Hence, it is possible that gL interface with specific chemokine receptors during the transmission of Herpesviridae. We conclude that the further understanding of the function of viral chemokine-like proteins in Herpesviridae infection may lead to development of novel prophylactic and therapeutic treatment.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Reference27 articles.
1. Whitley RJ: Herpesviruses. In Medical Microbiology. 4th edition. Edited by: Baron S. Galveston (TX); 1996.
2. Spear PG: Herpes simplex virus: receptors and ligands for cell entry. Cell Microbiol 2004,6(5):401-410. 10.1111/j.1462-5822.2004.00389.x
3. Roop C, Hutchinson L, Johnson DC: A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H. J Virol 1993,67(4):2285-2297.
4. Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG: Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 1998,280(5369):1618-1620. 10.1126/science.280.5369.1618
5. Maclean CA: HSV Entry and Spread. Meth Mol Med 1998, 10: 9-18.
Cited by
76 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献