Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6-Reference-Cited by-同舟云学术

Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6

Published:2011-02-10 Issue:1 Volume:8 Page:
ISSN:1743-422X
Container-title:Virology Journal
language:en
Short-container-title:Virol J

Author:

Zhefeng Meng,Huiliang Hu,Chao Qiu,Jun Sun,Jianxin Lu,Xiaoyan Zhang,Jianqing Xu

Abstract

Abstract A 7 amino acid deletion in Gag p6 (P6delta7) emerged in Chinese prevalent HIV-1 strain CRF07_BC from different epidemic regions. It is important to determine whether this mutation could be transmitted and spread. In this study, HIV-1 Gag sequences from 5 different epidemic regions in China were collected to trace the transmission linkage and to analyze genetic evolution of P6delta7 strains. The sequence analysis demonstrated that P6delta7 is a CRF07_BC specific deletion, different P6delta7 strains could be originated from different parental CRF07_BC recombinants in different epidemic regions, and the transmission of P6delta7 strain has occurred in IDU populations. This is for the first time to identify the transmission linkage for P6delta7 strains and serves as a wake-up call for further monitoring in the future; In addition, P6delta7 deletion may represent an evolutionary feature which might exert influence on the fitness of CRF07_BC strain.

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

Link

https://link.springer.com/content/pdf/10.1186/1743-422X-8-60.pdf

Reference18 articles.

1. Coren LV, Thomas JA, Chertova E, Sowder RC, Gagliardi TD, Gorelick RJ, Ott DE: Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1. J Virol 2007, 81: 10047-10054. 10.1128/JVI.02496-06

2. Pikora CA, Wittish C, Desrosiers RC: p6 gag of human and simian immunodeficiency viruses is tolerant to small in-frame deletions downstream of the late domain. Virology 2006, 346: 479-489. 10.1016/j.virol.2005.10.040

3. Bleiber G, Peters S, Martinez R, Cmarko D, Meylan P, Telenti A: The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro. J Gen Virol 2004, 85: 921-927. 10.1099/vir.0.19576-0

4. Yan-Hui Song, ZheFeng Meng, Xing Hui, Yuhua Ruan, Xinping Li, Ruolei Xin, Pengfei Ma, Peng Hong, Shao Yiming: Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6. Arch Virol 2007, 26: 1553-1558.

5. Wang L: Overview of the HIV/AIDS epidemic, scientific research and government responses in China. AIDS 2007,21(Suppl 8):S3-7. 10.1097/01.aids.0000304690.24390.c2

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A New HIV-1 K ₂₈ E ₃₂ -Reverse Transcriptase Variant Associated with the Rapid Expansion of CRF07_BC among Men Who Have Sex with Men;Microbiology Spectrum;2022-10-26

2. HIV‐1 genotype is independently associated with immunodeficiency progression among Chinese men who have sex with men: an observational cohort study;HIV Medicine;2019-12-21

3. Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B;Virologica Sinica;2019-12-11

4. HIV-1 CRF07_BC with a Seven Amino Acid Deletion in the gag p6 Region Dominates in HIV-1-Infected Men Who Have Sex with Men in China;AIDS Research and Human Retroviruses;2017-09

5. Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China;PLOS ONE;2017-04-12