A New HIV-1 K <sub>28</sub> E <sub>32</sub> -Reverse Transcriptase Variant Associated with the Rapid Expansion of CRF07_BC among Men Who Have Sex with Men-Reference-Cited by-同舟云学术

A New HIV-1 K ₂₈ E ₃₂ -Reverse Transcriptase Variant Associated with the Rapid Expansion of CRF07_BC among Men Who Have Sex with Men

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Han Jingwan¹,Zhou Yan-Heng²³⁴,Ma Yingying²,Zhu Guoxin¹,Zhang Dong¹,Zhu Bo¹,Cheng Tong⁵,Wang Lanfeng⁵,Wang Jian-Hua⁴,Li Lin¹^ORCID,Zhang Chiyu²^ORCID

Affiliation:

1. Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

2. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

3. Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan’an University, Yan’an, Shaanxi, China

4. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

5. Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

Abstract

HIV-1 has very high mutation rate that is correlated with the survival and adaption of the virus. The variants with higher transmissibility may be more selective advantage than the strains with higher virulence.

Funder

National Natural Science Foundation of China

State Key Laboratory of Pathogen and Biosecurity

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02545-22

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