Abstract
AbstractUpper gastrointestinal (GI) carcinomas are characterized as one of the deadliest cancer types with the highest recurrence rates. Their treatment is challenging due to late diagnosis, early metastasis formation, resistance to systemic therapy and complicated surgeries performed in poorly accessible locations. Current cancer medication face deficiencies such as high toxicity and systemic side-effects due to the non-specific distribution of the drug agent. Nanomedicine has the potential to offer sophisticated therapeutic possibilities through adjusted delivery systems. This review aims to provide an overview of novel approaches and perspectives on nanoparticle (NP) drug delivery systems for gastrointestinal carcinomas. Present regimen for the treatment of upper GI carcinomas are described prior to detailing various NP drug delivery formulations and their current and potential role in GI cancer theranostics with a specific emphasis on targeted nanodelivery systems. To date, only a handful of NP systems have met the standard of care requirements for GI carcinoma patients. However, an increasing number of studies provide evidence supporting NP-based diagnostic and therapeutic tools. Future development and strategic use of NP-based drug formulations will be a hallmark in the treatment of various cancers. This article seeks to highlight the exciting potential of novel NPs for targeted cancer therapy in GI carcinomas and thus provide motivation for further research in this field.
Publisher
Springer Science and Business Media LLC
Subject
General Engineering,General Materials Science
Reference196 articles.
1. M. Roser, H. Ritchie, Cancer. Our World in Data (2020). https://ourworldindata.org/cancer
2. A.D. Wagner, N.L. Syn, M. Moehler, W. Grothe, W.P. Yong, B.C. Tai, J. Ho, S. Unverzagt, Chemotherapy for advanced gastric cancer. Cochrane Database Syst. Rev. 8, CD004064 (2017)
3. C.-H. Shin, W.-Y. Lee, S.-W. Hong, Y.-G. Chang, Characteristics of gastric cancer recurrence five or more years after curative gastrectomy. Chin. J. Cancer Res. 28(5), 503 (2016)
4. L. Moletta, S. Serafini, M. Valmasoni, E.S. Pierobon, A. Ponzoni, C. Sperti, Surgery for recurrent pancreatic cancer: is it effective? Cancers 11(7), 991 (2019)
5. A.C. Society, Key Statistics for Pancreatic Cancer. https://www.cancer.org/cancer/pancreatic-cancer/about/key-statistics.html
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献