Author:
Ye Feng,Yu Yan,Hu Yuting,Lu Weiguo,Xie Xing
Abstract
Abstract
Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with CIN, and 62 healthy individuals. A substantial reduction of circulating dendritic cells and accordingly immunodepression may be associated with increased IL-6 and TGF-β in serum. These findings could give expression to the immunosuppression of circulating dendritic cells in patients with CC and CIN, thus, may indicate novel aspects of cervical carcinoma immune evasion.
Publisher
Springer Science and Business Media LLC
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