Author:
Murphy Jennifer R,Rawdon Caroline,Kelleher Ian,Twomey Deirdre,Markey Patrick S,Cannon Mary,Roche Richard AP
Abstract
Abstract
Background
Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk for psychosis, indicating that the MMN may be a potential biomarker for psychosis. However, the at risk samples included in MMN studies are characterised by pre-existing clinical symptomatology and significant functional decline which are related to MMN amplitude. These factors may be potential confounds in determining whether deficient MMN is present prior to clinical manifestation of the disorder. Therefore, investigating the MMN in the extended psychosis phenotype comprising adolescents with psychotic symptoms from the general population may provide important information on whether abnormal MMN is apparent in the earliest stages of risk.
Methods
Thirty six adolescents completed a duration deviant MMN task. Fourteen adolescents with psychotic symptoms comprised the at risk group and 22 with no psychotic symptoms comprised the Controls. The task consisted of 85% standard tones (25 ms) and 15% deviant tones (50 ms). The groups were compared on MMN and P3a amplitude and latency across frontocentral and temporal electrodes.
Results
Adolescents with psychotic symptoms were characterised by a reduction in MMN amplitude at frontal and temporal regions compared to the controls.
Conclusions
This is the first study to demonstrate impaired auditory discrimination for duration deviant tones in nonclinical adolescents with psychotic symptoms. These findings suggest that MMN amplitude may be a possible biomarker for vulnerability to psychosis.
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Reference51 articles.
1. Bodatsch M, Ruhrmann S, Wagner M, Muller R, Schultze-Lutter F, Frommann I: Prediction of psychosis by mismatch negativity. Biol Psychiatry. 2011, 69 (10): 959-966. 10.1016/j.biopsych.2010.09.057.
2. Umbricht D, Koller R, Schmid L, Skrabo A, Grubel C, Huber T: How specific are deficits in mismatch negativity generation to schizophrenia?. Biol Psychiatry. 2003, 53 (12): 1120-1131. 10.1016/S0006-3223(02)01642-6.
3. Naatanen R, Tiitinen H: Auditory Information Processing as Indexed by the Mismatch Negativity. Advances in Psychological Science Biological and Cognitive Aspects. Edited by: Sabourin M, Craik F, Robert M. 1998, Hove, UK: Psychology Press/Erlbaum (UK) Taylor and Francis, 145-170.
4. Winkler I, Karmos G, Naatanen R: Adaptive modeling of the unattended acoustic environment reflected in the mismatch negativity event-related potential. Brain Res. 1996, 742 (1-2): 239-252. 10.1016/S0006-8993(96)01008-6.
5. Cheour M: Development of Mismatch Negativity (MMN) during Infancy. Infant EEG and Event-Related Potentials: Studies in Developmental Psychology. Edited by: de Haan M. 2008, London: Psychology Press
Cited by
37 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献