Longitudinal change in mismatch negativity (MMN) but not in gamma-band auditory steady-state response (ASSR) is associated with psychological difficulties in adolescence

Author:

Usui Kaori12,Kirihara Kenji13,Araki Tsuyoshi14,Tada Mariko156,Koshiyama Daisuke1,Fujioka Mao1,Nishimura Ryoichi1,Ando Shuntaro17,Koike Shinsuke1689,Sugiyama Hiroshi1,Shirakawa Toru110,Toriyama Rie1,Masaoka Mio1,Fujikawa Shinya1,Endo Kaori7,Yamasaki Syudo7,Nishida Atsushi7,Kasai Kiyoto168

Affiliation:

1. The University of Tokyo Department of Neuropsychiatry, Graduate School of Medicine, , Tokyo, 113-8655 , Japan

2. National Institute of Mental Health, National Center of Neurology and Psychiatry Department of Community Mental Health & Law, , Tokyo, 187-8551 , Japan

3. The University of Tokyo Disability Services Office, , Tokyo, 113-8655 , Japan

4. Department of Neuropsychiatry, Teikyo University Hospital , Mizonokuchi, Tokyo, 213-8507 , Japan

5. The University of Tokyo Office for Mental Health Support, Center for Research on Counseling and Support Services, , Tokyo, 113-8655 , Japan

6. The University of Tokyo The International Research Center for Neurointelligence (WPI-IRCN), University of Tokyo Institutes for Advanced Study (UTIAS), , Tokyo, 113-0033 , Japan

7. Tokyo Metropolitan Institute of Medical Science Department of Psychiatry and Behavioral Sciences, , Tokyo , Japan

8. University of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM) , Tokyo, 113-8655 , Japan

9. The University of Tokyo Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, , Tokyo, 153-8902 , Japan

10. Tokyo Metropolitan University Department of Electrical Engineering and Computer Science, Faculty of Systems Design, , Tokyo, 192-039 7 Japan

Abstract

Abstract Adolescence is a critical period for psychological difficulties. Auditory mismatch negativity (MMN) and gamma-band auditory steady-state response (ASSR) are representative electrophysiological indices that mature during adolescence. However, the longitudinal association between MMN/ASSR and psychological difficulties among adolescents remains unclear. We measured MMN amplitude for duration and frequency changes and ASSR twice in a subsample (n = 67, mean age 13.4 and 16.1 years, respectively) from a large-scale population-based cohort. No significant longitudinal changes were observed in any of the electroencephalography indices. Changes in SDQ-TD were significantly associated with changes in duration MMN, but not frequency MMN and ASSR. Furthermore, the subgroup with higher SDQ-TD at follow-up showed a significant duration MMN decrease over time, whereas the subgroup with lower SDQ-TD did not. The results of our population neuroscience study suggest that insufficient changes in electroencephalography indices may have been because of the short follow-up period or non-monotonic change during adolescence, and indicated that the longitudinal association with psychological difficulties was specific to the duration MMN. These findings provide new insights that electrophysiological change may underlie the development of psychosocial difficulties emerging in adolescence.

Funder

Hounkai Foundation

Narishige Neuroscience Research Foundation

Takeda Science Foundation

Mitsubishi Foundation

Moonshot R&D

AMED

JSPS

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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