HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis-Reference-Cited by-同舟云学术

HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

Published:2020-07-13 Issue:1 Volume:21 Page:
ISSN:1474-760X
Container-title:Genome Biology
language:en
Short-container-title:Genome Biol

Author:

Karlebach Guy,Hansen Peter,Veiga Diogo FT,Steinhaus Robin,Danis Daniel,Li Sheng,Anczukow Olga,Robinson Peter N^ORCID

Abstract

AbstractWe present Hierarchical Bayesian Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts. HBA-DEALS attains state of the art or better performance for both expression and splicing and allows genes to be characterized as having differential gene expression, differential alternative splicing, both, or neither. HBA-DEALS analysis of GTEx data demonstrated sets of genes that show predominant DGE or DAST across multiple tissue types. These sets have pervasive differences with respect to gene structure, function, membership in protein complexes, and promoter architecture.

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1186/s13059-020-02072-6.pdf

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