Author:
Ma Mingsheng,Cao Run,Wang Wei,Wang Biying,Yang Yichen,Huang Yunchao,Zhao Guangqiang,Ye Lianhua
Abstract
Abstract
Objective
Although the significance of increased plasma D-dimer levels in activating coagulation and fibrinolysis has been reported, it is still controversial whether it can be used to predict the prognosis of lung cancer patients. This meta-analysis was performed to explore the beneficial role of plasma D-dimer as a prognostic factor in lung cancer patients according to a larger sample capacity.
Materials and methods
MEDLINE, EMBASE, and Cochrane Central databases were searched from inception to January 2021. The data are mainly hazard ratio(HR) with 95% confidence interval (CI) and Kaplan–Meier survival curves. The publication bias was examined by Egger’s test.
Results
Finally, a total of 28 studies, enrolling 8452 patients were included in the current meta-analysis. Our results showed that the OS (HR = 1.742, 95%CI:1.542–1.969, P < 0.001) and PFS (HR = 1.385, 95%CI:1.169–1.641, P = 0.003) in the high D-dimer group were significantly lower than those in the low D-dimer group. Subgroup analysis suggested that localization, detection methods and disease stage had an important effect on the prognosis.
Conclusion
This meta-analysis revealed that the high plasma D-dimer level leads to lower survival than in the low D-dimer level, which might provide an important clue for high plasma D-dimer level as an independent factor of poor prognosis in patients with lung cancer.
Funder
national natural science foundation of china
high-level health technical personnel of yunnan provincial health commission.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,General Medicine,Surgery,Pulmonary and Respiratory Medicine
Reference49 articles.
1. Ay C, Dunkler D, Pirker R, Thaler J, Quehenberger P, Wagner O, et al. High D-dimer levels are associated with poor prognosis in cancer patients. Haematologica. 2012;97(8):1158.
2. Tas F, Kilic L, Serilmez M, Keskin S, Sen F, Duranyildiz DJRM. Clinical and prognostic significance of coagulation assays in lung cancer. Respirat Med. 2013;107(3):451–7.
3. Hisada Y, Mackman NJB. Cancer-associated pathways and biomarkers of venous thrombosis. J Am Soc Hematol. 2017;130(13):1499–506.
4. Louneva N, Maity A. Plasma D-dimer levels are elevated in radiation oncology patients. Kennedy ARJRr. 2020;193(1):46–53.
5. Schorling RM, Pfrepper C, Golombek T, Cella CA, Muñoz-Unceta N, Siegemund R, et al. Evaluation of biomarkers for the prediction of venous thromboembolism in ambulatory cancer patients. Oncol Res Treatm. 2020;43(9):412–21.
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献