Venous thromboembolism in patients undergoing surgery for lung cancer: a <i>post hoc</i> analysis of the Cancer-VTE Registry-Reference-Cited by-同舟云学术

Venous thromboembolism in patients undergoing surgery for lung cancer: a post hoc analysis of the Cancer-VTE Registry

Published:2024-07-22 Issue: Volume: Page:
ISSN:1465-3621
Container-title:Japanese Journal of Clinical Oncology
language:en
Short-container-title:

Author:

Kawachi Riken¹^ORCID,Okano Tetsuya²,Awano Nobuyasu³^ORCID,Matsumoto Masaru⁴,Hosokawa Jun⁵,Takita Atsushi⁶,Oba Mari S⁷⁸⁹,Kunitoh Hideo¹⁰

Affiliation:

1. Department of Respiratory Surgery, Nihon University School of Medicine , 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610 , Japan

2. Department of Respiratory Medicine, Nippon Medical School Chiba Hokusoh Hospital , 1715 Kamagari, Inzai-shi, Chiba 270-1694 , Japan

3. Department of Respiratory Medicine, Japanese Red Cross Medical Center , 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935 , Japan

4. Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School , 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603 , Japan

5. Primary Medical Science Department, Daiichi Sankyo Co., Ltd. , 3-5-1 Nihonbashi-honcho, Chuo-ku, Tokyo 103-8246 , Japan

6. Data Intelligence Department, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710 , Japan

7. Department of Medical Statistics, Toho University , 5-21-16 Omorinishi, Ota-ku,Tokyo 143-8540 , Japan

8. Department of Clinical Data Science , Clinical Research & Education Promotion Division, , 4-1-1 Ogawa-higashi-cho, Kodaira-shi, Tokyo 187-8551 , Japan

9. National Center of Neurology and Psychiatry , Clinical Research & Education Promotion Division, , 4-1-1 Ogawa-higashi-cho, Kodaira-shi, Tokyo 187-8551 , Japan

10. Department of Medical Oncology, Japanese Red Cross Medical Center , 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935 , Japan

Abstract

Abstract The relationship between lung cancer surgery and venous thromboembolism (VTE) in Japan has not been elucidated. This was a post hoc analysis of the Cancer-VTE Registry. The 1057 patients who underwent surgery for lung cancer were divided into the surgery alone (SA) group (n = 598) and the surgery plus chemotherapy (SC) group (n = 459), and the 1-year incidences of VTE and cerebral ischemia were analyzed. In the SA and SC groups, composite VTE was observed in one (0.2%) and 15 (3.3%) patients, respectively, and cerebral ischemia was observed in eight (1.3%) and four (0.9%) patients, respectively. Lymph node metastasis was more common in patients with D-dimer >1.2 μg/ml (odds ratio: 1.781, P = .004). SA had a low risk of VTE but a high risk of cerebral ischemia. Chemotherapy increases the risk of VTE. The D-dimer level was related to VTE and advanced cancer.

Funder

Daiichi Sankyo Co., Ltd.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jjco/advance-article-pdf/doi/10.1093/jjco/hyae090/58663263/hyae090.pdf

Reference10 articles.

1. Venous thromboembolism in patients undergoing operations for lung cancer: a systematic review;Christensen;Ann Thorac Surg,2014

2. Venous thromboembolism in patients with cancer: design and rationale of a multicentre, prospective registry (Cancer-VTE Registry);Ohashi;BMJ Open,2018

3. Risk and timing of venous thromboembolism after surgery for lung cancer: a nationwide cohort study;Mørkved;Ann Thorac Surg,2024

4. Timing of symptomatic venous thromboembolism after surgery: meta-analysis;Singh;Br J Surg,2023

5. Venous thromboembolism in cancer patients: report of baseline data from the multicentre, prospective Cancer-VTE Registry;Ohashi;Japanese Journal of Clinical Oncology