Abstract
Abstract
Background
Good syndrome is a rare condition, manifesting as immunodeficiency due to hypogammaglobulinemia associated with thymoma. Herein, we present a patient with Good syndrome whose thymoma was resected after treatment of cytomegalovirus hepatitis.
Case presentation
The patient was a 45-year-old woman presenting with fever, cough, and nasal discharge, and was diagnosed with thymoma and hypogammaglobulinemia. She subsequently developed cytomegalovirus hepatitis that was treated by immunoglobulin. After resolution of the hepatitis, she underwent thymectomy through a left anterior thoracotomy. Her postoperative course was uneventful, and while receiving ongoing immunoglobulin therapy, she has been doing well without signs of infection.
Conclusions
Management of infections is important for patients with Good syndrome. To minimize the risk of perioperative infection, we should take care while planning the surgical approach and procedure.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,General Medicine,Surgery,Pulmonary and Respiratory Medicine
Reference8 articles.
1. Jansen A, van Deuren M, Miller J, Litzman J, de Gracia J, Sáenz-Cuesta M, et al. Good syndrome study group. Prognosis of good syndrome: mortality and morbidity of thymoma associated immunodeficiency in perspective. Clin Immunol. 2016;171:12–7.
2. Malphettes M, Gérard L, Galicier L, Boutboul D, Asli B, Szalat R, et al. Good syndrome: an adult-onset immunodeficiency remarkable for its high incidence of invasive infections and autoimmune complications. Clin Infect Dis. 2015;61:e13–9.
3. Thongngarm T, Boonyasiri A, Pradubpongsa P, Tesavibul N, Anekpuritanang T, Kreetapirom P, et al. Features and outcomes of immunoglobulin therapy in patients with good syndrome at Thailand's largest tertiary referral hospital. Asian Pac J Allergy Immunol. 2019;37:109–15.
4. Tarr PE, Sneller MC, Mechanic LJ, Economides A, Eger CM, Strober W, et al. Infections in patients with immunodeficiency with thymoma (good syndrome). Report of 5 cases and review of the literature. Medicine (Baltimore). 2001;80:123–33.
5. Koriyama N, Fukumoto O, Fukudome M, Aso K, Hagiwara T, Arimura K, et al. Successful treatment of good syndrome with cytomegalovirus duodenoenteritis using a combination of ganciclovir and immunoglobulin with high anti-cytomegalovirus antibody titer. Am J Med Sci. 2004;327:49–54.
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