Good syndrome combined with myelodysplastic syndrome and multiple microbial pulmonary infections: A case report and literature review

Abstract

Abstract Introduction Good syndrome (GS) is a rare acquired immunodeficiency disease characterized by thymoma and hypogammaglobulinemia that predisposes to the risk of recurrent infections with multiple pathogens. Case representation We describe the case of a 37-year-old male with GS who had a history of thymoma resection combined with myelodysplastic syndrome and was hospitalized multiple times for infections. The patient was admitted to our hospital with reoccurring fever, empirical antimicrobial therapy was ineffective, and Streptococcus pneumoniae, cytomegalovirus, cytomegalovirus, fine cyclic virus, Candida albicans, and Pneumocystis japonicus infections were identified by high-throughput sequencing technology (NGS) testing of alveolar lavage fluid, and the patient's symptoms resolved and immunity was improved with targeted anti-infective therapy. Conclusion When patients with thymoma have recurrent abnormal infections, immunologic testing should be performed to clarify whether GS is present, and anti-infective therapy should be aggressively administered.