Author:
Michels Julia D.,Meis Jan,Sturm Noemi,Bornitz Florian,von Schumann Selina,Weis Aline,Neetz Benjamin,Bentner Martina,Forstner Johanna,Litke Nicola,Wensing Michel,Erdmann Stella,Grobe Thomas,Frerk Timm,Kempa Axel,Neurohr Claus,Schneider Armin,Müller Michael,Herth Felix J. F.,Szecsenyi Joachim,Trudzinski Franziska C.,Trudzinski Franziska Christina,Iberl Gabriele,Müller Beatrice,Biehler Elena,Fleischhhauer Thomas,Fuchs Gerhard,Qreini Markus,Schubert-Haack Janina,Klingenberg Anja,Kempa Alex,Joves Biljana,Rheinhold Andreas,Ghiani Alessandro,Lutz Nina,Walcher Swenja,Tsitouras Konstantinos,Paderewska Joanna,Briese Selina,Andritschky Christoph,Gehrig Patrick,Sugg Joachim,Hirschmann Susanne,Britsch Simone,Straub Christa,Jabbour Claude,Hahn Michael,Krebs Jörg,Graf Peter-Tobias,Denzer Petra,Fiedler Mascha O.,Bomeken Miriane,Stier Sebastian,Terboven Tom,Merle Uta,Regula Jens,Müller Jens,Oltmanns Ute,Hennersdorf Marcus,Satir Neslihan,Borst Mathias,Mayer Brigitte,Reikow Wolfgang,Kredel Markus,Frey Konstantin,Wolff Holger,Seidlitz Florian,Bientzle Stefanie,Nohé Boris,Allgäuer Sebastian,Schöpp Alexej,Schlegel Christoph,Hübner Imke,Kuzniar Andrezj,Häberle Helene,Riessen Reimer,Schempf Benjamin,Rebenschütz Ingo,Straub Andreas,Kollum Marc,Winter Markus,Hartveg Paul,Junginger Andreas,Beck Helmut,Vogel Mathias,
Abstract
Abstract
Background
Invasive mechanical ventilation (IMV) is a standard therapy for intensive care patients with respiratory failure. With increasing population age and multimorbidity, the number of patients who cannot be weaned from IMV increases, resulting in impaired quality of life and high costs. In addition, human resources are tied up in the care of these patients.
Methods
The PRiVENT intervention is a prospective, mixed-methods interventional, multicentre study with a parallel comparison group selected from insurance claims data of the health insurer Allgemeine Ortskrankenkasse Baden-Württemberg (AOK-BW) conducted in Baden-Württemberg, Germany, over 24 months. Four weaning centres supervise 40 intensive care units (ICUs), that are responsible for patient recruitment. The primary outcome, successful weaning from IMV, will be evaluated using a mixed logistic regression model. Secondary outcomes will be evaluated using mixed regression models.
Discussion
The overall objective of the PRiVENT project is the evaluation of strategies to prevent long-term IMV. Additional objectives aim to improve weaning expertise in and cooperation with the adjacent Intensive Care Units.
Trial registration
This study is registered at ClinicalTrials.gov (NCT05260853).
Funder
the Federal Joint Committee
Universitätsklinikum Heidelberg
Publisher
Springer Science and Business Media LLC