Usefulness of HepaRG cells in the mitochondrial function assay for the estimation of potential risk of idiosyncratic drug-induced liver injury
Author:
Affiliation:
1. Toxicology Research Lab., Central Pharmaceutical Research Institute, JAPAN TOBACCO INC.
Publisher
Japanese Society of Toxicology
Link
https://www.jstage.jst.go.jp/article/fts/7/3/7_153/_pdf
Reference19 articles.
1. Aninat, C., Piton, A., Glaise, D., Le Charpentier, T., Langouët, S., Morel, F., Guguen-Guillouzo, C. and Guillouzo, A. (2006): Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab. Dispos., 34, 75-83.
2. Cerec, V., Glaise, D., Garnier, D., Morosan, S., Turlin, B., Drenou, B., Gripon, P., Kremsdorf, D., Guguen-Guillouzo, C. and Corlu, A. (2007): Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor. Hepatology, 45, 957-967.
3. Elaut, G., Henkens, T., Papeleu, P., Snykers, S., Vinken, M., Vanhaecke, T. and Rogiers, V. (2006): Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures. Curr. Drug Metab., 7, 629-660.
4. Goda, K., Muta, K., Yasui, Y., Oshida, S., Kitatani, K. and Takekoshi, S. (2019): Selenium and Glutathione-Depleted Rats as a Sensitive Animal Model to Predict Drug-Induced Liver Injury in Humans. International journal of molecular sciences, 20, 3141.
5. Goda, K., Takahashi, T., Kobayashi, A., Shoda, T., Kuno, H. and Sugai, S. (2016): Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury. J. Toxicol. Sci., 41, 605-615.
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